Recombinant Anti-CEACAM1 Antibody, Rabbit Monoclonal

EliteRmab®, manufactured by recombinant technology
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Recombinant Anti-CEACAM1 Antibody, Rabbit Monoclonal 产品信息

产品名称
Recombinant Anti-CEACAM1 Antibody, Rabbit Monoclonal
经验证的应用
ELISA
交叉反应
Reacts with: Mouse
特异性
Mouse CEACAM1
No cross-reactivity in ELISA with
Human CEACAM1
免疫原
Recombinant Mouse CEACAM1 / CD66a protein (Catalog#50571-M08H)
制备方法
This antibody was obtained from a rabbit immunized with purified, recombinant Mouse CEACAM1 / CD66a (rM CEACAM1 / CD66a; Catalog#50571-M08H; NP_001034274.1; Met1-Gly428).
来源
Monoclonal Rabbit IgG Clone #025
纯化
Protein A
缓冲液
0.2 μm filtered solution in PBS
偶联物
Unconjugated
状态
Liquid
运输方式
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
储存条件
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Recombinant Anti-CEACAM1 Antibody, Rabbit Monoclonal 经验证的应用

应用 推荐稀释比/用量
ELISA 1:5000-1:10000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Recombinant Anti-CEACAM1 Antibody, Rabbit Monoclonal: 别称

Anti-bb-1 Antibody; Anti-Bgp Antibody; Anti-Bgp1 Antibody; Anti-C-CAM Antibody; Anti-Cc1 Antibody; Anti-CD66a Antibody; Anti-Cea-1 Antibody; Anti-Cea-7 Antibody; Anti-Cea1 Antibody; Anti-Cea7 Antibody; Anti-Hv-2 Antibody; Anti-Hv2 Antibody; Anti-mCEA1 Antibody; Anti-Mhv-1 Antibody; Anti-MHVR Antibody; Anti-MHVR1 Antibody; Anti-mmCGM1 Antibody; Anti-mmCGM1a Antibody; Anti-mmCGM2 Antibody

CEACAM1 背景信息

The carcinoembryonic-antigen-related cell-adhesion molecule (CEACAM) family of proteins has been implicated in various intercellular-adhesion and intracellular-signalling-mediated effects that govern the growth and differentiation of normal and cancerous cells. CEACAM1, also known as biliary glycoprotein I (BGP I) and CD66a, is a member of the carcinoembryonic antigen (CEA) gene family which belongs to the immunoglobulin superfamily. The highly glycosylated CEACAM1 contains one N-terminal V-type Ig-like domain and three C2-type Ig-like domains within its ECD, and one ITIM motif and a calmodulin binding site in the cytoplasmic region. CEACAM1 is a surface glycoprotein expressed on various blood cells, epithelial cells, and vascular cells. It was described as an adhesion molecule mediating cell adhesion via both homophilic and heterophilic manners, and was detected on leukocytes, epithelia, and endothelia. Studies have revealed that CEACAM1 performs actions in multiple cellular processes including tissue differentiation, angiogenesis, apoptosis, metastasis, as well as the modulation of innate and adaptive immune responses.
全称
carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
参考文献
  • Gray-Owen SD, et al. (2006) CEACAM1: contact-dependent control of immunity. Nat Rev Immunol. 6(6): 433-46.
  • Gu A, et al. (2009) Role of Ceacam1 in VEGF induced vasculogenesis of murine embryonic stem cell-derived embryoid bodies in 3D culture. Exp Cell Res. 315(10): 1668-82.
  • Wong C, et al. (2009) CEACAM1 negatively regulates platelet-collagen interactions and thrombus growth in vitro and in vivo. Blood. 113(8): 1818-28.
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