Recombinant Anti-Coagulation Factor II Antibody, Rabbit Monoclonal

RRID Number: AB_2860502
EliteRmab®, manufactured by recombinant technology
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Recombinant Anti-Coagulation Factor II Antibody, Rabbit Monoclonal 产品信息

产品名称
Recombinant Anti-Coagulation Factor II Antibody, Rabbit Monoclonal
经验证的应用
ELISA
交叉反应
Reacts with: Mouse
特异性
Mouse Coagulation Factor II
No cross-reactivity in ELISA with
Mouse KLK1
Mouse KLK11
免疫原
Recombinant Mouse Coagulation Factor II / F2 protein (Catalog#50344-M08H)
制备方法
This antibody was obtained from a rabbit immunized with purified, recombinant Mouse Coagulation Factor II / F2 (rM Coagulation Factor II / F2; Catalog#50344-M08H; NP_034298.1; Met1-Gly618).
来源
Monoclonal Rabbit IgG Clone #046
纯化
Protein A
缓冲液
0.2 μm filtered solution in PBS
偶联物
Unconjugated
状态
Liquid
运输方式
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
储存条件
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Recombinant Anti-Coagulation Factor II Antibody, Rabbit Monoclonal 经验证的应用

应用 推荐稀释比/用量
ELISA 1:5000-1:10000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Recombinant Anti-Coagulation Factor II Antibody, Rabbit Monoclonal: 别称

Anti-Cf-2 Antibody; Anti-Cf2 Antibody; Anti-FII Antibody

Coagulation Factor II 背景信息

Coagulation Factor II Protein (FII, F2 Protein or Prothrombin) is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. Coagulation Factor II Protein (FII, F2 Protein) also plays a role in maintaining vascular integrity during development and postnatal life. Prothrombin / Coagulation Factor II is activated on the surface of a phospholipid membrane that binds the amino end of prothrombin / Coagulation Factor II and factor Va and Xa in Ca-dependent interactions; factor Xa removes the activation peptide and cleaves the remaining part into light and heavy chains. The activation process starts slowly because factor V itself has to be activated by the initial, small amounts of thrombin. Prothrombin / Coagulation Factor II is expressed by the liver and secreted in plasma. Defects in prothrombin / Coagulation Factor II are the cause of factor II deficiency (FA2D). It is very rare blood coagulation disorder characterized by mucocutaneous bleeding symptoms. The severity of the bleeding manifestations correlates with blood factor II levels. Defects in Coagulation Factor II are also a cause of susceptibility to thrombosis. It is a multifactorial disorder of hemostasis characterized by abnormal platelet aggregation in response to various agents and recurrent thrombi formation.
全称
coagulation factor II (thrombin)
参考文献
  • Danneberg J, et al. (1998) Reliable genotyping of the G-20210-A mutation of Coagulation Factor II (prothrombin). Clin Chem. 44(2): 349-51.
  • Redondo M, et al. (1999) Coagulation Factor s II, V, VII, and X, prothrombin gene 20210GA transition, and factor V Leiden in coronary artery disease: high factor V clotting activity is an independent risk factor for myocardial infarction. Arterioscler Thromb Vasc Biol. 19(4): 1020-5.
  • Miletich JP, et al. (1980) The synthesis of sulfated dextran beads for isolation of human plasma Coagulation Factor s II, IX, and X. Anal Biochem. 105(2): 304-10.
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