Anti-HER3/ERBB3 Antibody

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Anti-HER3/ERBB3 Antibody (Rabbit Monoclonal 抗体) 产品信息

产品名称
Anti-HER3/ERBB3 Antibody
经验证的应用
ELISA(Cap)
交叉反应
Reacts with: Mouse
特异性
Mouse HER3/ERBB3
免疫原
Recombinant Mouse ERBB3 / HER3 Protein (Catalog#51003-M08H)
制备方法
This antibody was obtained from a rabbit immunized with purified, recombinant Mouse ERBB3 / HER3 (rM ERBB3 / HER3; Catalog#51003-M08H; Q61526; Met1-His641).
来源
Monoclonal Rabbit IgG Clone #128
纯化
Protein A
缓冲液
0.2 μm filtered solution in PBS
偶联物
Unconjugated
状态
Liquid
运输方式
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
储存条件
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-HER3/ERBB3 Antibody (Rabbit Monoclonal 抗体) 经验证的应用

Notes
ELISA(Cap): This antibody will detect Mouse ERBB3 / HER3 in ELISA pair set (Catalog: # SEK51003). In a sandwich ELISA, it can be used as capture antibody when paired with (Catalog: # 51003-R138).
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-HER3/ERBB3 Antibody: 别称

Anti-C76256 Antibody; Anti-Erbb-3 Antibody; Anti-Erbb-3r Antibody; Anti-Erbb3 Antibody; Anti-Erbb3r Antibody; Anti-Her3 Antibody

HER3/ERBB3 背景信息

ErbB3, also known as Her3(human epidermal growth factor receptor3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin binding domain but has not an active kinase domain., and therefore can not mediate the intracellular signal transduction through protein phosphorylation. However, its heterodimer with ErbB2 or other EGFR members responsible for tyrosine phosphorylation forms a receptor complex with high affinity, and initiates the related pathway which lead to cell proliferation or differentiation. ErbB3 has been shown to implicated in numerous cancers, including prostate, bladder, and breast tumors. This protein has different isoforms derived from alternative splicing variants, and among which, the secreted isoform lacking the intermembrane region modulates the activity of membrane-bound form.
全称
erb-b2 receptor tyrosine kinase 3
参考文献
  • Kraus M.H., et al.,(1989), Isolation and characterization of ERBB3, a third member of the ERBB/epidermal growth factor receptor family: evidence for overexpression in a subset of human mammary tumors. Proc. Natl. Acad. Sci. U.S.A. 86:9193-9197.
  • Plowman G.D., et al., (1990), Molecular cloning and expression of an additional epidermal growth factor receptor-related gene.Proc. Natl. Acad. Sci. U.S.A. 87:4905-4909.
  • Katoh M., et al.,(1993), c-erbB3 gene encodes secreted as well as transmembrane receptor tyrosine kinase.Biochem. Biophys. Res. Commun. 192:1189-1197.
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