Recombinant Anti-IFNGR1 Antibody, Rabbit Monoclonal

EliteRmab®, manufactured by recombinant technology
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Recombinant Anti-IFNGR1 Antibody, Rabbit Monoclonal 产品信息

产品名称
Recombinant Anti-IFNGR1 Antibody, Rabbit Monoclonal
经验证的应用
ELISA(Cap),FCM,ICC/IF
交叉反应
Reacts with: Mouse
特异性
Mouse IFNGR1
免疫原
Recombinant Mouse IFNGR1 / CD119 Protein (Catalog#50705-M08H)
制备方法
This antibody was obtained from a rabbit immunized with purified, recombinant Mouse IFNGR1 / CD119 (rM IFNGR1 / CD119; Catalog#50705-M08H; P15261; Met1-Asp253).
来源
Monoclonal Rabbit IgG Clone #062
纯化
Protein A
缓冲液
0.2 μm filtered solution in PBS
偶联物
Unconjugated
状态
Liquid
运输方式
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
储存条件
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Recombinant Anti-IFNGR1 Antibody, Rabbit Monoclonal 经验证的应用

应用 推荐稀释比/用量
ICC-IF 1:20-1:100
FCM 1:25-1:100
ELISA(Cap) 1:250-1:2000
Notes
ELISA(Cap): This antibody will detect Mouse IFNGR1 / CD119 in ELISA pair set (Catalog: # SEK50705). In a sandwich ELISA, it can be used as capture antibody when paired with (Catalog: # 50705-R074).
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Recombinant Anti-IFNGR1 Antibody, Rabbit Monoclonal 图片

Immunofluorescence staining of mouse IFNGR1 in mouse splenocytes. Cells were fixed with 4% PFA, blocked with 10% serum, and incubated with rabbit anti-mouse IFNGR1 monoclonal antibody (1:60) at 4℃ overnight. Then cells were stained with the Alexa Fluor® 488-conjugated Goat Anti-rabbit IgG secondary antibody (green) and counterstained with DAPI (blue).
Flow cytometric analysis of Mouse IFNGR1(CD119) expression on BABL/c splenocytes. Cells were stained with purified anti-Mouse IFNGR1(CD119), then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.

Recombinant Anti-IFNGR1 Antibody, Rabbit Monoclonal: 别称

Anti-CD119 Antibody; Anti-Ifgr Antibody; Anti-IFN-gammaR Antibody; Anti-Ifngr Antibody; Anti-Nktar Antibody

IFNGR1 背景信息

The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alters the behavior of the cell. Some CD proteins do not take part in the cell signal process but have other functions such as cell adhesion. CD119 (cluster of differentiation 119), also known as IFNGR1 ( interferon-gamma receptor 1), is part of the heterodimeric gamma interferon receptor which consists of IFNGR1 (CD119) and IFNGR2. The IFNGR1 gene encodes the ligand-binding chain (alpha) of the interferon receptor while the IFNGR gene encodes the non-ligand binding partner. The ability of the interferon-γ was achieved through binding to the interferon receptor CD119. After binding, the products of activated T-lymphocytes interferon-γ exerts antiviral activity, growth inhibitory effect, and several immune- regulatory activities on a variety of cell types.
全称
interferon gamma receptor 1
参考文献
  • Zola H, et al. (2007) CD molecules 2006-human cell differentiation molecules. J Immunol Methods. 318 (1-2): 1-5.
  • Ho IC, et al. (2009) GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation. Nat Rev Immunol. 9 (2): 125-35.
  • Matesanz-Isabel J, et al. (2011) New B-cell CD molecules. Immunology Letters.134 (2): 104-12
  • Novick D, et al. (1987) The human interferon-gamma receptor. The journal of biological chemistry. 262 (18): 8483-7
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