Anti-IL-6R Antibody, Rabbit Polyclonal

Price:
Size:
Number:

Anti-IL-6R Antibody, Rabbit Polyclonal 产品信息

产品名称
Anti-IL-6R Antibody, Rabbit Polyclonal
经验证的应用
ELISA
交叉反应
Reacts with: Mouse
特异性
Mouse IL-6R
免疫原
Recombinant Mouse IL6RA protein (Catalog#50280-M08H)
制备方法
Produced in rabbits immunized with purified, recombinant Mouse IL6RA / CD126 (rM IL6RA; Catalog#50280-M08H; NP_034689.2; Ile 44-Glu 357). Total IgG was purified by Protein A affinity chromatography.
来源
Polyclonal Rabbit IgG
纯化
Protein A
缓冲液
0.2 μm filtered solution in PBS
偶联物
Unconjugated
状态
Liquid
运输方式
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
储存条件
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-IL-6R Antibody, Rabbit Polyclonal 经验证的应用

应用 推荐稀释比/用量
ELISA 1:1000-1:2000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-IL-6R Antibody, Rabbit Polyclonal: 别称

Anti-CD126 Antibody; Anti-IL-6R Antibody; Anti-Il6r Antibody; Anti-MGC30256 Antibody

IL-6R 背景信息

Interleukin 6 receptor (IL-6R) also known as CD126 (Cluster of Differentiation 126) is a type I cytokine receptor. The low concentration of a soluble form of IL-6 receptor (SIL-6R) acts as an agonist of IL-6 activity. In the IL-6R/CD126/IL6R system, both a membrane-bound IL-6R and a SIL-6R protein can mediate IL-6 signals into the cells through the interaction of gp130. The resulting IL-6/sIL-6R protein complex is also capable of binding to gp130 and inducing intracellular signaling. Through this so-called 'trans-signaling' mechanism, IL-6 can stimulate cells that lack an endogenous mIL-6R. High levels of IL-6 and SIL-6R have been reported in several chronic inflammatory and autoimmune diseases as well as in cancer.
全称
interleukin 6 receptor
研究领域
Related Pathways
  • AKT Signaling Pathway
    AKT Signaling Pathway
  • Jak-Stat Signaling Pathway
    Jak-Stat Signaling Pathway
  • Autophagy Pathway
    Autophagy Pathway
参考文献
  • Barill S, et al. (2000) The role of interleukin-6 and interleukin-6/interleukin-6 receptor-alpha complex in the pathogenesis of multiple myeloma. Eur Cytokine Netw. 11(4): 546-51.
  • Kang KW, et al. (2007) Novel role of IL-6/SIL-6R signaling in the expression of inducible nitric oxide synthase (iNOS) in murine B16, metastatic melanoma clone F10.9, cells. Free Radic Biol Med. 42(2): 215-27.
添加购物车成功! 添加购物车失败!请再次尝试 正在更新购物车,请稍后 U.S.A.