Recombinant Anti-IL1R1 Antibody, Rabbit Monoclonal

EliteRmab®, manufactured by recombinant technology
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Recombinant Anti-IL1R1 Antibody, Rabbit Monoclonal 产品信息

产品名称
Recombinant Anti-IL1R1 Antibody, Rabbit Monoclonal
经验证的应用
FCM
交叉反应
Reacts with: Mouse
特异性
Mouse IL1R1
免疫原
Recombinant Mouse IL-1R1 / CD121a Protein (Catalog#50807-M08H)
制备方法
This antibody was obtained from a rabbit immunized with purified, recombinant Mouse IL-1R1 / CD121a (rM IL-1R1 / CD121a; Catalog#50807-M08H; P13504; Met1-Lys338).
来源
Monoclonal Rabbit IgG Clone #191
纯化
Protein A
缓冲液
0.2 μm filtered solution in PBS
偶联物
Unconjugated
状态
Liquid
运输方式
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
储存条件
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Recombinant Anti-IL1R1 Antibody, Rabbit Monoclonal 经验证的应用

应用 推荐稀释比/用量
FCM 1:25-1:100
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Recombinant Anti-IL1R1 Antibody, Rabbit Monoclonal 图片

Flow cytometric analysis of IL1R1(CD121a) expression on NIH3T3 cells. Cells were stained with purified anti-Mouse IL1R1(CD121a), then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.

Recombinant Anti-IL1R1 Antibody, Rabbit Monoclonal: 别称

Anti-CD121a Antibody; Anti-CD121b Antibody; Anti-IL-1R1 Antibody; Anti-IL-iR Antibody; Anti-Il1r-1 Antibody

IL1R1 背景信息

Interleukin 1 receptor, type I (IL-1R1) also known as CD121a (Cluster of Differentiation 121a), is an interleukin receptor. IL-1R1/CD121a is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein is a receptor for interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I (IL1R1/IL1RA). IL-1R1/CD121a is an important mediator involved in many cytokines induced immune and inflammatory responses. This protein has been characterized by pharmacological and molecular techniques in the mouse brain. The spindle-shaped astrocytes enclose the wound, separating the healthy from damaged neural tissue. The shape change and subsequent repair processes are IL-1β activity-dependent, acting through the IL-1 type 1 receptor (IL-1R1), as co-application of the IL-1type 1 receptor antagonist protein (IL-1ra) blocks IL-1β induced effects. In the spleen, a slight increase in IL-1R ACP and IL-1R1 was observed during the first hours following LPS stimulation. In conclusion, IL-1R AcP mRNA is expressed in the brain and in other tissues where IL-1R1/CD121a transcripts are found. However, the regulation of its expression is distinct from IL-1R1/CD121a. The high level of expression and the lack of regulation of IL-1R AcP transcripts in the brain under inflammatory conditions suggest that the protein might be constitutively expressed in excess.
全称
interleukin 1 receptor, type I
研究领域
Related Pathways
  • IL1 signaling pathway
    IL1 signaling pathway
参考文献
  • Dale M, et al. (1999). "Interleukin-1 receptor cluster: gene organization of IL1R2, IL1R1, IL1RL2 (IL-1Rrp2), IL1RL1 (T1/ST2), and IL18R1 (IL-1Rrp) on human chromosome 2q.". Genomics 57 (1): 177-9.
  • Joos L, et al. (2001). "Association of IL-1beta and IL-1 receptor antagonist haplotypes with rate of decline in lung function in smokers.". Thorax 56 (11): 863-6.
  • Vigers GP, et al. (1997). "Crystal structure of the type-I interleukin-1 receptor complexed with interleukin-1beta.". Nature 386 (6621): 190-4.
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