Recombinant Anti-IL2RG Antibody (PE), Rabbit Monoclonal

EliteRmab®, manufactured by recombinant technology
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Recombinant Anti-IL2RG Antibody (PE), Rabbit Monoclonal 产品信息

产品名称
Recombinant Anti-IL2RG Antibody (PE), Rabbit Monoclonal
经验证的应用
FCM
交叉反应
Reacts with: Mouse
特异性
Mouse IL2RG
免疫原
Recombinant Mouse CD132 / IL2RG protein (Catalog#50087-M08H)
制备方法
This antibody was obtained from a rabbit immunized with purified, recombinant Mouse CD132 / IL2RG (rM CD132 / IL2RG; Catalog#50087-M08H; NP_038591.1; Met1-Ala263) and conjugated with PE under optimum conditions, the unreacted PE was removed.
来源
Monoclonal Rabbit IgG Clone #011
纯化
Protein A
缓冲液
Aqueous solution containing 0.5% BSA and 0.09% sodium azide
偶联物
PE
浓度
10 μl/Test, 0.1 mg/ml
状态
Liquid
运输方式
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
储存条件
This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.

Recombinant Anti-IL2RG Antibody (PE), Rabbit Monoclonal 图片

Flow cytometric analysis of mouse IL2RG(CD132) expression on mouse splenocytes. BABL/c splenocytes were stained with PE-conjugated anti-Mouse IL2RG(CD132). The histogram were derived from gated events with the forward and side light-scatter characteristics of viable lymphocytes.

Recombinant Anti-IL2RG Antibody (PE), Rabbit Monoclonal: 别称

Anti-CD132 Antibody; Anti-gamma(c) Antibody; Anti-gc Antibody; Anti-[g]c Antibody

IL2RG 背景信息

The common gamma chain (γc) (or CD132), also known as interleukin-2 receptor subunit gamma or IL2RG, is a member of the type I cytokine receptor family expressed on most lymphocyte (white blood cell) populations, and its gene is found on the X-chromosome of mammals. The common gamma chain (γc) (or IL2RG), is a cytokine receptor subunit that is common to the receptor complexes for at least six different interleukin receptors: IL-2, IL-4, IL-7, IL-9, IL-15, and the interleukin-21 receptor. It is a component of multiple cytokine receptors that are essential for lymphocyte development and function. X-linked severe combined immunodeficiency (X-SCID) is a rare and potentially fatal disease caused by mutations of IL2RG, the gene encoding IL2RG. IL2RG was demonstrated to be a component of the IL-4 receptor based on chemical cross-linking data, the ability of IL2RG to augment IL-4 binding affinity. The observation that IL-2R gamma is a functional component of the IL-4 receptor, together with the finding that IL-2R gamma associates with the IL-7 receptor, begins to elucidate why a deficiency of this common gamma chain (gamma c) has a profound effect on lymphoid function and development, as seen in X-linked severe combined immunodeficiency.
全称
interleukin 2 receptor, gamma
Related Pathways
  • Common G-Chain signaling pathway
    Common G-Chain signaling pathway
参考文献
  • Russell SM, et al. (1993) Interleukin-2 receptor gamma chain: a functional component of the interleukin-4 receptor. Science. 262 (5141): 1880-3.
  • Miyazaki T, et al. (1994) Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits. Science. 266 (5187): 1045-7.
  • Takeshita T, et al. (1992) Cloning of the gamma chain of the human IL-2 receptor. Science. 257 (5068): 379-82.
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