Anti-Kallikrein 6 Antibody, Rabbit Polyclonal

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Anti-Kallikrein 6 Antibody, Rabbit Polyclonal 产品信息

产品名称
Anti-Kallikrein 6 Antibody, Rabbit Polyclonal
经验证的应用
ELISA
交叉反应
Reacts with: Mouse
特异性
Mouse Kallikrein 6
免疫原
Recombinant Mouse KLK6 / Kallikrein 6 / Neurosin protein
制备方法
Produced in rabbits immunized with purified, recombinant Mouse KLK6 / Kallikrein 6 / Neurosin (NP_035307.2; Met 8-Leu 253). Total IgG was purified by Protein A affinity chromatography.
来源
Polyclonal Rabbit IgG
纯化
Protein A
缓冲液
0.2 μm filtered solution in PBS
偶联物
Unconjugated
状态
Liquid
运输方式
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
储存条件
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-Kallikrein 6 Antibody, Rabbit Polyclonal 经验证的应用

应用 推荐稀释比/用量
ELISA 1:1000-1:2000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-Kallikrein 6 Antibody, Rabbit Polyclonal: 别称

Anti-AI849898 Antibody; Anti-BSP Antibody; Anti-Bssp Antibody; Anti-Klk29 Antibody; Anti-MSP Antibody; Anti-neurosin Antibody; Anti-Prss18 Antibody; Anti-Prss9 Antibody

Kallikrein 6 背景信息

KLK6 (kallikrein-related peptidase 6), also known as Klk7, belongs to the peptidase S1 family, Kallikrein subfamily. Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. KLK6 is a serine protease that exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Klk7 shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein, and extracellular matrix proteins such as fibronectin, laminin, vitronectin, and collagen. KLK6 degrades alpha-synuclein and prevents its polymerization, indicating that KLK6 may be involved in the pathogenesis of Parkinson's disease and other synucleinopathies. Klk7 may be involved in the regulation of axon outgrowth following spinal cord injury. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control cells, suggesting a role in invasion and metastasis.
全称
kallikrein-related peptidase 6
参考文献
  • Krenzer S, et al. (2011) Expression and function of the kallikrein-related peptidase 6 in the human melanoma microenvironment. J Invest Dermatol. 131(11):2281-8.
  • Nathalie HV, et al. (2009) High kallikrein-related peptidase 6 in non-small cell lung cancer cells: an indicator of tumour proliferation and poor prognosis. J Cell Mol Med. 13(9B):4014-22.
  • Kim JT, et al. (2011) Up-regulation and clinical significance of serine protease kallikrein 6 in colon cancer. Cancer. 117(12):2608-19.
  • Scarisbrick IA, et al. (2011) Functional role of kallikrein 6 in regulating immune cell survival. PLoS One. 6(3):e18376.
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