Anti-KIRREL3 Antibody, Rabbit Polyclonal

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Anti-KIRREL3 Antibody, Rabbit Polyclonal 产品信息

产品名称
Anti-KIRREL3 Antibody, Rabbit Polyclonal
经验证的应用
ELISA,IHC-P
交叉反应
Reacts with: Mouse
特异性
Mouse KIRREL3
免疫原
Recombinant Mouse KIRREL3 / NEPH2 protein (Catalog#50339-M08H)
制备方法
Produced in rabbits immunized with purified, recombinant Mouse KIRREL3 / NEPH2 (rM KIRREL3 / NEPH2; Catalog#50339-M08H; Q8BR86-1; Met 1-Ala 535). KIRREL3 / NEPH2 specific IgG was purified by Mouse KIRREL3 / NEPH2 affinity chromatography.
来源
Polyclonal Rabbit IgG
纯化
Protein A & Antigen Affinity
缓冲液
0.2 μm filtered solution in PBS
偶联物
Unconjugated
状态
Liquid
运输方式
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
储存条件
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-KIRREL3 Antibody, Rabbit Polyclonal 经验证的应用

应用 推荐稀释比/用量
ELISA 1:5000-1:10000
IHC-P 1:2500-1:10000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-KIRREL3 Antibody, Rabbit Polyclonal 图片

Immunochemical staining of mouse KIRREL3 in mouse kidney with rabbit polyclonal antibody (1:5000, formalin-fixed paraffin embedded sections). The left panel: tissue incubated with primary antibody; The right panel: tissue incubated with the mixture of primary antibody and antigen (recombinant protein).

Anti-KIRREL3 Antibody, Rabbit Polyclonal: 别称

Anti-1500010O20Rik Antibody; Anti-2900036G11Rik Antibody; Anti-mKIAA1867 Antibody; Anti-NEPH2 Antibody; Anti-SST4 Antibody

KIRREL3 背景信息

Kin of IRRE-like protein 3 (KIRREL3) also known as nin of irregular chiasm-like protein 3 or nephrin-like protein 2 (NEPH2) is a member of the nephrin-like protein family of transmembrane proteins, which includes NEPH1 (KIRREL) and NEPH3 (KIRREL2). KIRREL3/NEPH2 is expressed in the fetal and adult brain, and also in podocytes of kidney glomeruli. The cytoplasmic domains of KIRREL3/NEPH2 interact with the C-terminus of podocin, also expressed in the podocytes, cells involved in ensuring size- and charge-selective ultrafiltration. Mutations in KIRREL3/NEPH2 are associated with mental retardation autosomal dominant type 4. KIRREL3/NEPH2 expression is turned on in migrating Nucleogenesis of the pontine nucleus (PN) neurons only after they enter the presumptive nuclear region. KIRREL3/NEPH2 knockdown disrupted the nuclear organization of PN presumably by changing the migratory behavior of PN neurons inside the nuclear region. Moreover, overexpression of the cytoplasmic region of KIRREL3, which can sequester intracellular signaling of endogenous KIRREL3, resulted in similar phenotypes. Overall, these results suggest KIRREL3 is involved in the Nucleogenesis of the PN through the control of neuronal migration inside the nucleus.
全称
kin of IRRE like 3 (Drosophila)
参考文献
  • Bhalla K, et al. (2008) Alterations in CDH15 and KIRREL3 in patients with mild to severe intellectual disability. Am J Hum Genet. 83(6): 703-13.
  • Gerke P, et al. (2005) NEPH2 is located at the glomerular slit diaphragm, interacts with nephrin and is cleaved from podocytes by metalloproteinases. J Am Soc Nephrol. 16(6): 1693-702.
  • Gerke P, et al. (2006) Neuronal expression and interaction with the synaptic protein CASK suggest a role for Neph1 and Neph2 in synaptogenesis. J Comp Neurol. 498(4): 466-75.
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