Recombinant Anti-PD-L1 Antibody, Rabbit Monoclonal

RRID Number: AB_2860469
EliteRmab®, manufactured by recombinant technology
1/1
Price:
Size:
Number:

Recombinant Anti-PD-L1 Antibody, Rabbit Monoclonal 产品信息

产品名称
Recombinant Anti-PD-L1 Antibody, Rabbit Monoclonal
经验证的应用
FCM
交叉反应
Reacts with: Mouse
特异性
Mouse PD-L1
免疫原
Recombinant Mouse PD-L1 / B7-H1 / CD274 protein (Catalog#50010-M08H)
制备方法
This antibody was obtained from a rabbit immunized with purified, recombinant Mouse PD-L1 / B7-H1 / CD274 (rM PD-L1 / B7-H1 / CD274; Catalog#50010-M08H; NP_068693.1; Met1-Thr238).
来源
Monoclonal Rabbit IgG Clone #485
纯化
Protein A
缓冲液
0.2 μm filtered solution in PBS
偶联物
Unconjugated
状态
Liquid
运输方式
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
储存条件
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Recombinant Anti-PD-L1 Antibody, Rabbit Monoclonal 经验证的应用

应用 推荐稀释比/用量
FCM 1:25-1:100
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Recombinant Anti-PD-L1 Antibody, Rabbit Monoclonal 图片

Flow cytometric analysis of Mouse CD274 expression on BABL/c splenocytes. Cells were stained with purified anti-Mouse CD274, then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.

Recombinant Anti-PD-L1 Antibody, Rabbit Monoclonal: 别称

Anti-A530045L16Rik Antibody; Anti-B7h1 Antibody; Anti-Pdcd1l1 Antibody; Anti-Pdcd1lg1 Antibody; Anti-Pdl1 Antibody

PD-L1 背景信息

Programmed death-1 ligand-1 (PD-L1, CD274, B7-H1) has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been demonstrated to play a role in the regulation of immune responses and peripheral tolerance. PD-L1/B7-H1 is a member of the growing B7 family of immune molecules and this protein contains one V-like and one C-like Ig domain within the extracellular domain, and together with PD-L2, are two ligands for PD1 which belongs to the CD28/CTLA4 family expressed on activated lymphoid cells. By binding to PD1 on activated T-cells and B-cells, PD-L1 may inhibit ongoing T-cell responses by inducing apoptosis and arresting cell-cycle progression. Accordingly, it leads to growth of immunogenic tumor growth by increasing apoptosis of antigen specific T cells and may contribute to immune evasion by cancers. PD-L1 thus is regarded as promising therapeutic target for human autoimmune disease and malignant cancers.
全称
CD274 molecule
研究领域
参考文献
  • Iwai Y, et al. (2002) Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade. Proc Natl Acad Sci U S A. 99(19): 12293-7.
  • Ghebeh H, et al. (2006) The B7-H1 (PD-L1) T lymphocyte-inhibitory molecule is expressed in breast cancer patients with infiltrating ductal carcinoma: correlation with important high-risk prognostic factors. Neoplasia. 8(3): 190-8.
  • Salih HR, et al. (2006) The role of leukemia-derived B7-H1 (PD-L1) in tumor-T-cell interactions in humans. Exp Hematol. 34(7): 888-94.
  • Wilcox RA, et al. (2009) B7-H1 (PD-L1, CD274) suppresses host immunity in T-cell lymphoproliferative disorders. Blood. 114(10): 2149-58.
  • Ruggiero A, et al. (2009) Crystal structure of PD-L1, a ribosome inactivating protein from Phytolacca dioica L. leaves with the property to induce DNA cleavage. Biopolymers. 91(12): 1135-42.
添加购物车成功! 添加购物车失败!请再次尝试 正在更新购物车,请稍后 U.S.A.