Recombinant Anti-SELL/CD62L Antibody (FITC), Rabbit Monoclonal

EliteRmab®, manufactured by recombinant technology
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Recombinant Anti-SELL/CD62L Antibody (FITC), Rabbit Monoclonal 产品信息

产品名称
Recombinant Anti-SELL/CD62L Antibody (FITC), Rabbit Monoclonal
经验证的应用
FCM
交叉反应
Reacts with: Mouse
特异性
Mouse SELL/CD62L
免疫原
Recombinant Mouse SELL protein (Catalog#50045-M08H)
制备方法
This antibody was obtained from a rabbit immunized with purified, recombinant Mouse SELL / CD62L / L-selectin (rM SELL / CD62L / L-selectin; Catalog#50045-M08H; NP_035476.1; Met 1-Asn 332) and conjugated with FITC under optimum conditions, the unreacted FITC was removed.
来源
Monoclonal Rabbit IgG Clone #414
纯化
Protein A
缓冲液
Aqueous solution containing 0.5% BSA and 0.09% sodium azide
偶联物
FITC
浓度
5 μl/Test, 0.1 mg/ml
状态
Liquid
运输方式
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
储存条件
This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.

Recombinant Anti-SELL/CD62L Antibody (FITC), Rabbit Monoclonal 图片

Flow cytometric analysis of CD62L expression on spleen lymphocytes.

Recombinant Anti-SELL/CD62L Antibody (FITC), Rabbit Monoclonal: 别称

Anti-AI528707 Antibody; Anti-CD62L Antibody; Anti-L-selectin Antibody; Anti-LECAM-1 Antibody; Anti-Lnhr Antibody; Anti-Ly-22 Antibody; Anti-Ly-m22 Antibody; Anti-Lyam-1 Antibody; Anti-Lyam1 Antibody

SELL/CD62L 背景信息

L-selectin (SELL), also known as CD62L, is a key adhesion molecule that regulates both the migration of leukocytes at sites of inflammation and the recirculation of lymphocytes between blood and lymphoid tissues. It belongs to the selectin family of proteins, and consisting of a large, highly glycosylated, extracellular domain, a single spanning transmembrane domain and a small cytoplasmic tail. L-selectin is the only selectin expressed on leukocytes and mediates a number of leukocyte-endothelial interactions. L-selectin acts as a "homing receptor" for leukocytes to enter secondary lymphoid tissues via high endothelial venules. Ligands present on endothelial cells will bind to leukocyte expressing L-selectin, slowing leukocyte trafficking through the blood, and facilitating entry into a secondary lymphoid organ at that point. L-selectin-mediated lymphocyte recirculation is required for maintaining the appropriate tissue distribution of lymphocyte subpopulations including naïve and effector subsets such as regulatory T cells. In addition, L-selectin-mediated entry into peripheral lymph nodes is required for optimal induction of lymphocyte homeostatic proliferation during lymphopenia. Importantly, L-selectin has been shown to have both adhesive and signaling functions during leukocyte migration. L-selectin has also been shown to mediate leukocyte recruitment during chronic inflammatory and autoimmune diseases and thus is a potential therapeutic target for drug development.
全称
selectin L
参考文献
  • Smalley DM, et al. (2005) L-selectin: mechanisms and physiological significance of ectodomain cleavage. J Cell Mol Med. 9(2): 255-66.
  • Grailer JJ, et al. (2009) L-selectin: role in regulating homeostasis and cutaneous inflammation. J Dermatol Sci. 56(3): 141-7.
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