Anti-Syndecan-1/CD138 Antibody, Rabbit Polyclonal

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Anti-Syndecan-1/CD138 Antibody, Rabbit Polyclonal 产品信息

产品名称
Anti-Syndecan-1/CD138 Antibody, Rabbit Polyclonal
经验证的应用
ELISA
交叉反应
Reacts with: Mouse
特异性
Mouse Syndecan-1/CD138
免疫原
Recombinant Mouse Syndecan-1 / SDC1 / CD138 protein (Catalog#50641-M08H)
制备方法
Produced in rabbits immunized with purified, recombinant Mouse Syndecan-1 / SDC1 / CD138 (Catalog#50641-M08H; NP_035649.1; Met1-Glu252). Total IgG was purified by Protein A affinity chromatography.
来源
Polyclonal Rabbit IgG
纯化
Protein A
缓冲液
0.2 μm filtered solution in PBS
偶联物
Unconjugated
状态
Liquid
运输方式
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
储存条件
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-Syndecan-1/CD138 Antibody, Rabbit Polyclonal 经验证的应用

应用 推荐稀释比/用量
ELISA 1:1000-1:2000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-Syndecan-1/CD138 Antibody, Rabbit Polyclonal: 别称

Anti-AA408134 Antibody; Anti-AA409076 Antibody; Anti-CD138 Antibody; Anti-Sstn Antibody; Anti-syn-1 Antibody; Anti-Synd Antibody; Anti-Synd1 Antibody

Syndecan-1/CD138 背景信息

Syndecan-1 also known as SDC1 and CD138, is the most extensively studied member of the syndecan family. It is found mainly in epithelial cells, but its expression is developmentally regulated during embryonic development. Syndecan-1/SDC1/CD138 has been shown to mediate cell adhesion to several ECM molecules, and to act as a coreceptor for fibroblast growth factors, potent angiogenic growth factors involved also in differentiation. Syndecan-1/SDC1/CD138 expression is reduced during malignant transformation of various epithelia, and this loss correlates with the histological differentiation grade of squamous cell carcinomas, lacking from poorly differentiated tumours. In squamous cell carcinomas of the head and neck, positive syndecan-1 expression correlates with a more favourable prognosis. Experimental studies on the role of Syndecan-1 in malignant transformation have shown that Syndecan-1/SDC1/CD138 expression is associated with the maintenance of epithelial morphology, anchorage-dependent growth and inhibition of invasiveness in vitro.
全称
syndecan 1
参考文献
  • Inki P, et al. (1996) The role of syndecan-1 in malignancies. Ann Med. 28(1): 63-7.
  • Subramanian SV, et al. (1997) Regulated shedding of syndecan-1 and -4 ectodomains by thrombin and growth factor receptor activation. J Biol Chem. 272(23): 14713-20.
  • Park PW, et al. (2001) Exploitation of syndecan-1 shedding by Pseudomonas aeruginosa enhances virulence. Nature. 411(6833): 98-102.
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