Anti-TBG Antibody, Rabbit Polyclonal

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Anti-TBG Antibody, Rabbit Polyclonal 产品信息

产品名称
Anti-TBG Antibody, Rabbit Polyclonal
经验证的应用
ELISA
交叉反应
Reacts with: Mouse
特异性
Mouse TBG
免疫原
Recombinant Mouse SerpinA7 protein (Catalog#50313-M08H)
制备方法
Produced in rabbits immunized with purified, recombinant Mouse SerpinA7 (rM SerpinA7; Catalog#50313-M08H; NP_808588.3; Met 1-Gln 418). Total IgG was purified by Protein A affinity chromatography.
来源
Polyclonal Rabbit IgG
纯化
Protein A
缓冲液
0.2 μm filtered solution in PBS
偶联物
Unconjugated
状态
Liquid
运输方式
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
储存条件
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-TBG Antibody, Rabbit Polyclonal 经验证的应用

应用 推荐稀释比/用量
ELISA 1:1000-1:2000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Citation List

Anti-TBG Antibody, Rabbit Polyclonal: 别称

Anti-C730040N12Rik Antibody; Anti-Serpin A7 Antibody; Anti-Tbg Antibody; Anti-Thyroxine Binding Globulin Antibody

TBG 背景信息

Thyroxine-binding globulin, also known as T4-binding globulin, Serpin A7 and TBG, is a secreted protein which belongs to theserpin family. TBG is synthesized primarily in theliveras a 54 kDa protein.TBG is genomically aserpin, although it has no inhibitory function like many other members of this class of proteins. TBG binds thyroid hormone in circulation. It is one of three proteins(along with transthyretin and albumin) responsible for carrying thethyroidhormones thyroxine(T4) and 3,5,3’-triiodothyronine (T3) in the bloodstream. Of these three proteins, TBG has the highest affinity for T4 and T3, but is present in the lowest concentration. Despite its low concentration, TBG carries the majority of T4 inserum. Due to the very low serum concentration of T4 and T3, TBG is rarely more than 25% saturated with itsligand. Unlike transthyretin and albumin, TBG has a single binding site for T4/T3. TBG tests are sometimes used in finding the reason for elevated or diminished levels of thyroid hormone.
全称
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
参考文献
  • Flink I.L., et al.,(1986), Complete amino acid sequence of human thyroxine-binding globulin deduced from cloned DNA: close homology to the serine antiproteases. Proc. Natl. Acad. Sci. U.S.A. 83:7708-7712.
  • Akbari M.T., et al., (1993), The structure of the human thyroxine binding globulin (TBG) gene.Biochim. Biophys. Acta 1216:446-454.
  • Hayashi Y., et al.,(1993), Human thyroxine-binding globulin gene: complete sequence and transcriptional regulation.Mol. Endocrinol. 7:1049-1060.
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