Recombinant Anti-UCHL3 Antibody, Rabbit Monoclonal

EliteRmab®, manufactured by recombinant technology
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Recombinant Anti-UCHL3 Antibody, Rabbit Monoclonal 产品信息

产品名称
Recombinant Anti-UCHL3 Antibody, Rabbit Monoclonal
经验证的应用
IHC-P
交叉反应
Reacts with: Mouse
特异性
Mouse UCHL3
No cross-reactivity in ELISA with
Human UCHL3
免疫原
Recombinant Mouse UCHL3 protein (Catalog#50692-M07E)
制备方法
This antibody was obtained from a rabbit immunized with purified, recombinant Mouse UCHL3 (rM UCHL3; Catalog#50692-M07E; Q9JKB1; Glu2-Ala230).
来源
Monoclonal Rabbit IgG Clone #204
纯化
Protein A
缓冲液
0.2 μm filtered solution in PBS
偶联物
Unconjugated
状态
Liquid
运输方式
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
储存条件
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Recombinant Anti-UCHL3 Antibody, Rabbit Monoclonal 经验证的应用

应用 推荐稀释比/用量
IHC-P 1:100-1:500
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Recombinant Anti-UCHL3 Antibody, Rabbit Monoclonal 图片

Immunochemical staining of mouse UCHL3 in mouse heart with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections).
Immunochemical staining of mouse UCHL3 in mouse brain with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections).
Immunochemical staining of mouse UCHL3 in mouse bone with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections).

UCHL3 背景信息

Ubiquitin carboxyl-terminal hydrolase isozyme L3, also known as UCH-L3, Ubiquitin thioesterase L3 and UCHL3, is a ubiquitin-protein hydrolase that belongs to the peptidase C12 family. It is involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. UCHL3 is highly expressed in heart, skeletal muscle, and testis. UCHL1 and UCHL3 are two of the deubiquitinating enzymes expressed in the brain. These phenotypes indicate the importance of UCHL1 and UCHL3 in the regulation of the central nervous system. UCHL3 functions as a de-ubiquitinating enzyme where lack of its hydrolase activity may result in the prominent accumulation of ubiquitinated proteins and subsequent induction of stress responses in skeletal muscle. UCHL3 has also been identified as a tumor-specific antigen in colon cancer.
全称
ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
参考文献
  • Wood,M.A. et al., 2005, Hippocampus  15 (5):610-21.
  • Kwon,J. et al., 2006, Exp Anim  55 (1):35-43.
  • Setsuie,R. et al., 2009, Neurochem Int  54 (5-6):314-21.
  • Setsuie,R. et al., 2010, Neurochem Int  56 (8):911-8.
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