Anti-ADAM17 Antibody, Rabbit Polyclonal

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Anti-ADAM17 Antibody, Rabbit Polyclonal 产品信息

产品名称
Anti-ADAM17 Antibody, Rabbit Polyclonal
经验证的应用
ELISA
交叉反应
Reacts with: Rat
特异性
Rat ADAM17
免疫原
Recombinant Rat ADAM17 protein (Catalog#80350-R08H)
制备方法
Produced in rabbits immunized with purified, recombinant Rat ADAM17 (Catalog#80350-R08H; Q9Z1K9; Met1-Asp563). ADAM17 specific IgG was purified by Rat ADAM17 affinity chromatography.
来源
Polyclonal Rabbit IgG
纯化
Protein A & Antigen Affinity
缓冲液
0.2 μm filtered solution in PBS
偶联物
Unconjugated
状态
Liquid
运输方式
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
储存条件
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-ADAM17 Antibody, Rabbit Polyclonal 经验证的应用

应用 推荐稀释比/用量
ELISA 1:5000-1:10000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

ADAM17 背景信息

ADAM17 is a member of the ADAM protein family of disintegrins and metalloproteases. ADAM17 is ubiquitously expressed in the human colon, with increased activity in the colonic mucosa of patients with ulcerative colitis, a main form of inflammatory bowel disease. The expression of ADAM17 may be inhibited by ethanol. It is involved in the processing of tumor necrosis factor alpha (TNF-α) at the surface of the cell, and from within the intracellular membranes of the trans-Golgi network. ADAM17 also plays a role in the release of a diverse variety of membrane-anchored cytokines, cell adhesion molecules, receptors, ligands, and enzymes. ADAM17 may play a prominent role in the Notch signaling pathway, during the proteolytic release of the Notch intracellular domain (from the Notch1 receptor) that occurs following ligand binding.
全称
ADAM metallopeptidase domain 17
Related Pathways
  • Notch Signaling
    Notch Signaling
参考文献
  • Poghosyan. et al., 2002, J Biol Chem. 277 (7): 4999-5007.
  • Li Y. et al., 2006, Blood. 108 (7): 2275-9.
  • Peiretti. et al., 2003, J Cell Sci. 116 (10): 1949-57.
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