Anti-CD40 Antibody (FITC), Mouse Monoclonal

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Anti-CD40 Antibody (FITC), Mouse Monoclonal 产品信息

产品名称
Anti-CD40 Antibody (FITC), Mouse Monoclonal
经验证的应用
FCM
交叉反应
Reacts with: Rat
特异性
Rat CD40
免疫原
Recombinant Rat CD40 / TNFRSF5 protein (Catalog#80151-R08H)
制备方法
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Rat CD40 / TNFRSF5 (rR CD40 / TNFRSF5; Catalog#80151-R08H; NP_599187.1; Met1-Arg193) and conjugated with FITC under optimum conditions, the unreacted FITC was removed.
来源
Monoclonal Mouse IgG1 Clone #01
纯化
Protein A
缓冲液
Aqueous solution containing 0.5% BSA and 0.09% sodium azide
偶联物
FITC
浓度
10 μl/Test, 0.1 mg/ml
状态
Liquid
运输方式
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
储存条件
This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.

Anti-CD40 Antibody (FITC), Mouse Monoclonal 图片

Flow cytometric analysis of Rat CD40 expression on rat splenocytes. SD splenocytes were stained with FITC-conjugated anti-Rat CD40 and FITC conjugated anti-Rat CD3 (BD Pharmingen™ Cat. No. 557354). The dot plots were derived from events with the forward and side light-scatter characteristics of intact cells.

CD40 背景信息

CD40, also known as TNFRSF5, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins. CD40 protein plays an essential role in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. CD40 protein is expressed in B cells, dendritic cells, macrophages, endothelial cells, and several tumor cell lines. Defects in CD40 result in hyper-IgM immunodeficiency type 3 (HIGM3). In addition, CD40/CD40L interaction is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis.
全称
CD40 molecule, TNF receptor superfamily member 5
研究领域
Related Pathways
  • B Cell Receptor Signaling Pathway
    B Cell Receptor Signaling Pathway
参考文献
  • van Kooten C, et al. (2000). CD40-CD40 ligand. J Leukoc Biol. 67 (1): 2-17.
  • Bhushan A, et al. (2002). CD40:CD40L interactions in X-linked and non-X-linked hyper-IgM syndromes. Immunol Res. 24 (3): 311-24.
  • Chatzigeorgiou A, et al. (2009) CD40/CD40L signaling and its implication in health and disease. Biofactors. 35(6): 474-83.
  • Li R, et al. (2009) Expression of CD40 and CD40L in Gastric Cancer Tissue and Its Clinical Significance. Int J Mol Sci. 10(9): 3900-17.
  • Lievens D, et al. (2009) The multi-functionality of CD40L and its receptor CD40 in atherosclerosis. Thromb Haemost. 102(2): 206-14.
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