Recombinant Anti-CD89 Antibody, Rabbit Monoclonal

EliteRmab®, manufactured by recombinant technology
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Recombinant Anti-CD89 Antibody, Rabbit Monoclonal 产品信息

产品名称
Recombinant Anti-CD89 Antibody, Rabbit Monoclonal
经验证的应用
ELISA
交叉反应
Reacts with: Rat
特异性
Rat CD89
No cross-reactivity in ELISA with
Rat FCGR1a
免疫原
Recombinant Rat CD89 / FCAR protein (Catalog#80014-R08H)
制备方法
This antibody was obtained from a rabbit immunized with purified, recombinant Rat CD89 / FCAR (rR CD89 / FCAR; Catalog#80014-R08H; NP_973721.1; Met1-Asn228).
来源
Monoclonal Rabbit IgG Clone #013
纯化
Protein A
缓冲液
0.2 μm filtered solution in PBS
偶联物
Unconjugated
状态
Liquid
运输方式
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
储存条件
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Recombinant Anti-CD89 Antibody, Rabbit Monoclonal 经验证的应用

应用 推荐稀释比/用量
ELISA 1:5000-1:10000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Recombinant Anti-CD89 Antibody, Rabbit Monoclonal: 别称

Anti-CD89 Antibody

CD89 背景信息

FCAR, also called FcαRI or CD89, is a type I transmembrane receptor for Fc region of IgA which is the most abundant immunoglobulin in mucosal areas but is only the second most common antibody isotype in serum. This receptor is present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, especially phagocytes located in mucosal areas. Upon ligand IgA binding, FcαRI associates with the FcR γ signaling molecule bearing the immunoreceptor tyrosine-based activation motif (ITAM) through a unique charge-based mechanism and triggers multiple cell-mediated immune responses. It has been reported that Fc RI is a dual-function receptor that can mediate both inflammatory and anti-inflammatory responses depending on the type of interaction with its ligand. Sustained aggregation of FCAR results in activation of target-cell functions such as antigen presentation and cytokine release. In contrast, Monomeric targeting with serum IgA or with a variety of anti-FcαRI Fab fragments triggers an inhibitory response and additionally induces apoptosis. FcαRI thus play an fundamental role in preventing tumor development and growth, as well as in controlling inflammation.
全称
Fc fragment of IgA receptor
参考文献
  • Maliszewski, C.R. et al., 1990, J. Exp. Med. 172: 1665-1672.
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