Anti-CEACAM1 Antibody (APC), Mouse Monoclonal

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Anti-CEACAM1 Antibody (APC), Mouse Monoclonal 产品信息

产品名称
Anti-CEACAM1 Antibody (APC), Mouse Monoclonal
经验证的应用
FCM
交叉反应
Reacts with: Rat
特异性
Rat CEACAM1
免疫原
Recombinant Rat CEACAM‑1/CD66a Protein (Catalog#80224-R08H)
制备方法
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Rat CEACAM‑1/CD66a (rR CEACAM‑1/CD66a; Catalog#80224-R08H; Met1-Ser422) and conjugated with APC under optimum conditions, the unreacted APC was removed.
来源
Monoclonal Mouse IgG1 Clone #03
纯化
Protein A
缓冲液
Aqueous solution containing 0.5% BSA and 0.09% sodium azide
偶联物
APC
浓度
2 μl/Test, 0.1 mg/ml
状态
Liquid
运输方式
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
储存条件
This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.

Anti-CEACAM1 Antibody (APC), Mouse Monoclonal 图片

Flow cytometric analysis of Rat CEACAM1(CD66a) expression on SD rat splenocytes. Cells were stained with APC-conjugated anti-Rat CEACAM1(CD66a). The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.

CEACAM1 背景信息

The carcinoembryonic-antigen-related cell-adhesion molecule (CEACAM) family of proteins has been implicated in various intercellular-adhesion and intracellular-signalling-mediated effects that govern the growth and differentiation of normal and cancerous cells. CEACAM1, also known as biliary glycoprotein I (BGP I) and CD66a, is a member of the carcinoembryonic antigen (CEA) gene family which belongs to the immunoglobulin superfamily. The highly glycosylated CEACAM1 contains one N-terminal V-type Ig-like domain and three C2-type Ig-like domains within its ECD, and one ITIM motif and a calmodulin binding site in the cytoplasmic region. CEACAM1 is a surface glycoprotein expressed on various blood cells, epithelial cells, and vascular cells. It was described as an adhesion molecule mediating cell adhesion via both homophilic and heterophilic manners, and was detected on leukocytes, epithelia, and endothelia. Studies have revealed that CEACAM1 performs actions in multiple cellular processes including tissue differentiation, angiogenesis, apoptosis, metastasis, as well as the modulation of innate and adaptive immune responses.
全称
carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
参考文献
  • Gray-Owen SD, et al. (2006) CEACAM1: contact-dependent control of immunity. Nat Rev Immunol. 6(6): 433-46.
  • Gu A, et al. (2009) Role of Ceacam1 in VEGF induced vasculogenesis of murine embryonic stem cell-derived embryoid bodies in 3D culture. Exp Cell Res. 315(10): 1668-82.
  • Wong C, et al. (2009) CEACAM1 negatively regulates platelet-collagen interactions and thrombus growth in vitro and in vivo. Blood. 113(8): 1818-28.
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