Recombinant Anti-HGF Antibody, Rabbit Monoclonal

EliteRmab®, manufactured by recombinant technology
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Recombinant Anti-HGF Antibody, Rabbit Monoclonal 产品信息

产品名称
Recombinant Anti-HGF Antibody, Rabbit Monoclonal
经验证的应用
ELISA
交叉反应
Reacts with: Rat
特异性
Rat HGF
免疫原
Recombinant Rat HGF/Hepatocyte Growth Factor Protein (Catalog#80429-RNAH)
制备方法
This antibody was obtained from a rabbit immunized with purified, recombinant Rat HGF/Hepatocyte Growth Factor (rR HGF/Hepatocyte Growth Factor; Catalog#80429-RNAH; NP_058713.1; Met1-Leu728).
来源
Monoclonal Rabbit IgG Clone #052
纯化
Protein A
缓冲液
0.2 μm filtered solution in PBS
偶联物
Unconjugated
状态
Liquid
运输方式
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
储存条件
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Recombinant Anti-HGF Antibody, Rabbit Monoclonal 经验证的应用

应用 推荐稀释比/用量
ELISA 1:5000-1:10000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

HGF 背景信息

Hepatocyte growth factor, also known as HGF, contains 4 kringle domains, 1 PAN domain, and 1 peptidase S1 domain. It belongs to the peptidase S1 family, plasminogen subfamily. The hepatocyte growth factor is secreted by mesenchymal cells as a single inactive polypeptide and is cleaved by serine proteases into a 69-kDa alpha-chain and 34-kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule. The hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor, and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility and matrix invasion give it a central role in angiogenesis, tumorogenesis, and tissue regeneration. HGF is a potent mitogen for mature parenchymal hepatocyte cells, seems to be an hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. HGF has no detectable protease activity. Defects in hepatocyte growth factor are the cause of deafness autosomal recessive type 39. A form of profound prelingual sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
全称
hepatocyte growth factor (hepapoietin A; scatter factor)
研究领域
参考文献
  • Naldini L, et al. (1991) Scatter factor and hepatocyte growth factor are indistinguishable ligands for the MET receptor. EMBO J. 10(10):2867-78.
  • Comoglio, et al. (1993) Structure, biosynthesis and biochemical properties of the HGF receptor in normal and malignant cells. 65:131-65.
  • Hahn W, et al. (2011) Enhanced cardioprotective effects by coexpression of two isoforms of hepatocyte growth factor from naked plasmid DNA in a rat ischemic heart disease model. The Journal of Gene Medicine. 13(10):549-55.
  • Bottaro DP, et al. (1991) Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product. Science. 251(4995):802-4.
  • Impaired integrin α5 /β1 -mediated hepatocyte growth factor release by stellate cells of the aged liver
    Author
    Rohn, F;Kordes, C;Buschmann, T;Reichert, D;Wammers, M;Poschmann, G;Stühler, K;Benk, AS;Geiger, F;Spatz, JP;Häussinger, D;
    Year
    2020
    Journal
    Aging Cell
    Application
    IF
  • The role of IL-6 trans-signaling in liver regeneration after partial hepatectomy Dissertation
    Author
    Modares, NF;
    Year
    2020
    Journal
    Thesis
    Application
    Elisa; Immunocytochemistry
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