Anti-Nectin-2 Antibody, Rabbit Polyclonal

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Anti-Nectin-2 Antibody, Rabbit Polyclonal 产品信息

产品名称
Anti-Nectin-2 Antibody, Rabbit Polyclonal
经验证的应用
ELISA,IHC-P
交叉反应
Reacts with: Rat
特异性
Rat Nectin-2
免疫原
Recombinant Rat CD112 / Nectin-2 / PVRL2 protein (Catalog#80327-R08H)
制备方法
Produced in rabbits immunized with purified, recombinant Rat CD112 / Nectin-2 / PVRL2 (Catalog#80327-R08H; Q9ESS6; Met1-Gly351). CD112 / Nectin-2 / PVRL2 specific IgG was purified by Rat CD112 / Nectin-2 / PVRL2 affinity chromatography.
来源
Polyclonal Rabbit IgG
纯化
Protein A & Antigen Affinity
缓冲液
0.2 μm filtered solution in PBS
偶联物
Unconjugated
状态
Liquid
运输方式
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
储存条件
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-Nectin-2 Antibody, Rabbit Polyclonal 经验证的应用

应用 推荐稀释比/用量
ELISA 1:5000-1:10000
IHC-P 1:100-1:500
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-Nectin-2 Antibody, Rabbit Polyclonal 图片

Immunochemical staining of rat PVRL2 in rat testis with rabbit polyclonal antibody (1:300, formalin-fixed paraffin embedded sections).

Nectin-2 背景信息

Cluster of Differentiation 112 (CD112), also known as poliovirus receptor related protein 2 (PVRL2 or PRR2), is a single-pass type I transmembrane glycoprotein belonging to the Immunoglobulin superfamily. CD112 protein also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and thus is involved in cell to cell spreading of these viruses. CD112 protein has been identified as the ligand for DNAM-1 (CD226), and the interaction of CD226/CD112 protein can induce NK cell- and CD8+ T cell-mediated cytotoxicity and cytokine secretion. CD112 has been regarded as a critical component in allergic reactions, and accordingly may function as a novel target for anti-allergic therapy.
全称
poliovirus receptor-related 2 (herpesvirus entry mediator B)
参考文献
  • Bachelet I, et al. (2006) Mast cell costimulation by CD226/CD112 (DNAM-1/Nectin-2): a novel interface in the allergic process. J Biol Chem. 281(37): 27190-6.
  • Wang L, et al. (2009) Molecular cloning, characterization and three-dimensional modeling of porcine nectin-2/CD112. Vet Immunol Immunopathol. 132(2-4): 257-63.
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