Anti-Reg3A Antibody, Rabbit Polyclonal

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Anti-Reg3A Antibody, Rabbit Polyclonal 产品信息

产品名称
Anti-Reg3A Antibody, Rabbit Polyclonal
经验证的应用
ELISA,IHC-P
交叉反应
Reacts with: Rat
特异性
Rat Reg3A
免疫原
Recombinant Rat REG3A protein (Catalog#80258-R08H)
制备方法
Produced in rabbits immunized with purified, recombinant Rat REG3A (Catalog#80258-R08H; BAA04904.1; Met1-Gln174). REG3A specific IgG was purified by Rat REG3A affinity chromatography.
来源
Polyclonal Rabbit IgG
纯化
Protein A & Antigen Affinity
缓冲液
0.2 μm filtered solution in PBS
偶联物
Unconjugated
状态
Liquid
运输方式
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
储存条件
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-Reg3A Antibody, Rabbit Polyclonal 经验证的应用

应用 推荐稀释比/用量
ELISA 1:5000-1:10000
IHC-P 1:500-1:2000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-Reg3A Antibody, Rabbit Polyclonal 图片

Immunochemical staining of rat REG3A in rat rectum with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections).
Immunochemical staining of rat REG3A in rat small intestine (from 2 donors) with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections).

Anti-Reg3A Antibody, Rabbit Polyclonal: 别称

Anti-Pap2 Antibody; Anti-Reg3 Antibody; Anti-REG3A Antibody

Reg3A 背景信息

Regenerating islet-derived protein 3-alpha, also known as Regenerating islet-derived protein III-alpha, REG-3-alpha, REG3A, and HIP, is secreted protein that contains one C-type lectin domain. REG3A is constitutively expressed in intestine, and is a pancreatic secretory protein that may be involved in cell proliferation or differentiation. It is overexpressed during the acute phase of pancreatitis and in some patients with chronic pancreatitis. REG3A and REG1A proteins are both involved in liver and pancreatic regeneration and proliferation. REG3A is also a stress protein involved in the control of bacterial proliferation. REG3A is down-regulated in most primary human gastric cancer cells, and might be useful in the diagnosis of gastric cancer. Additionally, REG3A is a target of beta-catenin signaling in Huh7 hepatoma cells. The REG1A and REG3A are downstream targets of the Wnt pathway during liver tumorigenesis.
全称
regenerating family member 3 alpha
参考文献
  • Cavard C, et al. (2006) Overexpression of regenerating islet-derived 1 alpha and 3 alpha genes in human primary liver tumors with beta-catenin mutations. Oncogene. 25(4): 599-608.
  • Choi B, et al. (2007) Downregulation of regenerating islet-derived 3 alpha (REG3A) in primary human gastric adenocarcinomas. Exp Mol Med. 39(6): 796-804.
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