Anti-Her2/ERBB2 Antibody, Mouse Monoclonal

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Anti-Her2/ERBB2 Antibody, Mouse Monoclonal 产品信息

产品名称
Anti-Her2/ERBB2 Antibody, Mouse Monoclonal
经验证的应用
ELISA
交叉反应
Reacts with: Rhesus
特异性
Rhesus Her2/ERBB2
Has cross-reactivity in ELISA with
Human ErbB2
No cross-reactivity in ELISA with
Human EGFR
Human ERBB3
Human ERBB4
Human cell lysate (293 cell line)
免疫原
Recombinant Rhesus HER2 / ErbB2 protein (Catalog#90020-K08H)
制备方法
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Rhesus HER2 / ErbB2 (Catalog#90020-K08H; XP_001090430.1; Met 1-Thr 652). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
来源
Monoclonal Mouse IgG1 Clone #10A7F7
纯化
Protein A
缓冲液
0.2 μm filtered solution in PBS
偶联物
Unconjugated
状态
Liquid
运输方式
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
储存条件
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-Her2/ERBB2 Antibody, Mouse Monoclonal 经验证的应用

应用 推荐稀释比/用量
ELISA 1:1000-1:2000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Her2/ERBB2 背景信息

Epidermal growth factor receptor 2 (HER2), also known as ErbB2, NEU, and CD34, is a type I membrane glycoprotein, and belongs to the epidermal growth factor (EGF) receptor family. HER2 protein cannot bind growth factors due to the lacking of ligand binding domain of its own and autoinhibited constitutively. However, HER2 forms a heterodimer with other ligand-bound EGF receptor family members, therefore stabilizes ligand binding and enhances kinase-mediated activation of downstream molecules. HER2 plays a key role in development, cell proliferation and differentiation. HER2 gene has been reported to associate with malignancy and a poor prognosis in numerous carcinomas, including breast, prostate, ovarian, lung cancers and so on.
全称
erb-b2 receptor tyrosine kinase 2
参考文献
  • Krawczyk N, et al. (2009) HER2 status on persistent disseminated tumor cells after adjuvant therapy may differ from initial HER2 status on primary tumor. Anticancer Res. 29(10): 4019-24.
  • Phage display as a tool for development of novel therapeutics for breast cancer
    Author
    Cabral, MJCD;
    Year
    2014
    Journal
    Thesis
    Application
    ELISA
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