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Antibody chimerization refers to changing the antibody constant region from one species to another. The early application of such a technology is the chimerization of mouse antibody into mouse-human chimeric antibody to reduce the antibody's immunogenicity as a clinical product in human use. In fact, this technology can be applied in many other situations. For example, one could change a human antibody's constant region into a mouse constant gene and generate a human-mouse chimeric antibody. For the same argument, one could change the constant regions from one species to another, as well as change from one subtype to another subtype within the same species. In theory, all the above stated scenario could all be possible, but practically, making it happen is not as straight and could be fairly challenging.
Sino Biological has genetically manipulated many antibodies by switching antibody's constant regions to meet certain desired features. Our experiences covers not only human and mouse antibodies, but also rabbit, rat, canine antibodies. Our professional scientists and engineers are at your service to support your antibody chimerization needs.
How to Submit a Request for Antibody Humanization Service?
If you are interested in using our antibody humanization services to support your antibody discovery and development program, please contact us by leaving an on-line message or send us your detailed request to CROfirstname.lastname@example.org. Based on the quantity and quality requirement of your request, a formal quote will be send back to you for your review, comment, and/or acceptance.