Antibody /Mab Production / Purification Service: High Monomer Purity

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Antibody / Mab Production / Purification Service: High Monomer Purity

Host Cells: HEK293 or CHO cell (please specify, cost for production in CHO cell is higher)
Technology: Recombinant technology, transient transfection, Serum-free cell culture
Purification: Affinity protein A/G/L chromatography column purification
Anion and Caton Exchange Chromatography &
Size Exclusion Chromatography Column (SEC) for antibody fragment
and aggregate removals to achieve high monomer purity
Polishing: Purified antibodies meeting required QC specifications
(quantities to be specified by customer)
Deliverable: Depending on cell growth rate and scale of production
Quality Specification: >95-99% monomer antibody purity by HP-SEC
(cost and timeline may increase with increased monomer purity due to the need for process
development, polishing, and QC testing)
Antibody Types: human, mouse, rat, rabbit, canine, rhesus IgG antibodies
- We have experience in producing IgA, IgM, and IgE antibodies
Applications: antibody discovery, antibody library, antibody engineering, Fab & ScFv conversion to Mab
suitable for antibody characterization, in vitro testing, in vivo testing
Quotation: on-line request form or e-mail request to CRO-service@sinobiological.com

Track Records & Key Facts

300 Staff
> 80 Bioreactors
> 30 Purification System
> 10,000 Mab Production
> 5000 Protein Bulks
> 5000 antibody development
1-100mg Mab Production in 3-6 weeks
1-10 g Mab Production in 6-8 weeks
Preferred CRO Partner for Multiple Top-10 Pharmas

More Antibody /Mab Production Services

Antibody /Mab Purification Services

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Features of Antibody Production Services at Sino Biological

  • Record Speed in Antibody Production
  • From Mab Sequence to Purified
  • 1-100 mg Mab in 3-6 weeks
  • 1-10 gram Mab in 6-8 weeks
  • GLP Grade Antibody Production
  • High Monomer Purity: up to 99%
  • Low Endotoxin Level: up to 0.05 EU/mg
  • Unmatched Experience in Antibody Production
  • >gt;10,000 Mab Production
  • Almost 100% success rate
Cutting-Edge Technology Unlimited Capacity Unbelievable Cost-Saving

High Monomer Purity Antibody Production & Purification Service Description

Monomer purity is a critical parameter for monoclonal antibody therapeutic candidate in pre-clinical in vivo studies, because aggregate can affect antibody's bioactivity and immunogenicity as well as pharmacokinetics. Therefore, for in vivo studies, antibody's monomer purity typically needs to be controlled above 95%, and in some high-dose studies, one would need to increase the monomer purity to as high as 99%.

Monomer purity can be increased by removing antibody aggregates and fragments through polishing purification steps such as ion exchange chromatography, hydrophobic chromatography, and size exclusion chromatography. For some antibodies that are prone to forming new aggregates in certain types of buffer, polishing steps are not sufficient to increase monomer purity because new aggregates are formed in the polishing process. In such a case, one would need to optimize the formulation ......< Learn More>

Biology CRO Service
Biology CRO Service Introduction
Antibody Production & Development CRO Service
- Antibody CRO Service Description
- Antibody Service Q&A
- Antibody /Mab Production CRO Service
- Antibody Purification Service
-- Antibody Purification Service Description
-- Antibody /Mab Production / Purification Service: High Monomer Purity
High Monomer Purity Antibody Purification Service Description
-- low endotoxin antibody production service
Low Endotoxin Antibody Purification Service Description
-- GLP Grade Antibody /Mab Production / Purification Service
GLP Grade Antibody Production Service Description
-- IgG Antibody /Mab Production & Purification Service
IgG Antibody Production & Purification Service Description
-- IgA Antibody/Mab Production & Purification Service
IgA Antibody Production & Purification Service Description
-- IgM Antibody /Mab Production / Purification Service
IgM Antibody Production & Purification Service Description
-- Mouse IgG1 Antibody /Mab Production / Purification Service
Mouse IgG1 IgG Antibody Production & Purification Service Description
-- Mouse IgG2a Antibody /Mab Production / Purification Service
Mouse IgG2a Antibody Production & Purification Service Description
-- Mouse IgG2b Antibody /Mab Production / Purification Service
Mouse IgG2b Antibody Production & Purification Service Description
-- Mouse IgG3 Antibody /Mab Production / Purification Service
Mouse IgG3 Antibody Production & Purification Service Description
-- Rat IgG Antibody /Mab Production / Purification Service
Rat IgG Antibody Production & Purification Service Description
-- Rabbit IgG Antibody /Mab Production / Purification Service
Rabbit IgG Antibody Production & Purification Service Description
-- Total Polyclonal Antibody Production / Purification Service
Total Polyclonal Antibody Production & Purification Service Description
-- Antigen-Specific Polyclonal Antibody Production / Purification Service
Antigen Specific Polyclonal Antibody Service Description
- Antibody Humanization Service / Services
- Custom Antibody Development Service / Services
Protein Production CRO Service
Transient Transfection Service: Mammalian Cell Culture
Molecular Biology CRO Service