Tumor Microenvironment

Tumor Microenvironment (TME) is a complex integrated system, which can be divided into immune microenvironment dominated by immune cells and non-immune microenvironment dominated by fibroblasts. There is a phenomenon called infiltration, which is some types of cells that can enter the tumor tissue. These infiltrating lymphocytes, including T lymphocytes, B lymphocytes, Macrophage, NK lymphocytes, Myeloid derived suppressor cells and Dendritic cells, called tumor infiltration lymphocytes, mediate the immunosuppressive tumor microenvironment, which help tumor cells achieve immune escape, and promote the malignant development of the tumor.

In addition, there are infiltration of fibroblasts, vascular endothelial cells, and stromal cells in the tumor, which constitute the non-immune microenvironment of the tumor. Tumor-associated fibroblasts can release stromal cell-derived factors, etc., to promote the growth of tumor cells and tumor angiogenesis. Vascular endothelial cells mainly mediate the formation of tumor cells and jointly provide assistance for tumor formation and metastasis.

Sino Biological lists the classification tree of Tumor Microenvironment, click to see all the related molecules/targets and research reagents of them.

Tumor Microenvironment

Tumor Microenvironment

Myeloid-derived Suppressor Cells (MDSC)

Myeloid-derived Suppressor Cells (MDSC)

MDSC Intracellular Signaling Factors

MDSC Intracellular Signaling Factors

MDSC Phenotyping - Negative Markers

MDSC Phenotyping - Negative Markers