Angiogenesis

Angiogenesis is the formation and remodelling of new blood vessels and capillaries from growth of pre-existing blood vessels. It normally occurs during wound healing and embryonic development, but is also required for tumour growth and metastasis in cancer.And it mainly includes degradation of vascular basement membrane during activation;Activation, proliferation and migration of vascular endothelial cells;Reconstruction and formation of new blood vessels and blood vessel networks. In a word, it is a complex process involving a variety of molecules in a variety of cells.

Sino Biological lists the classification tree of Angiogenesis, click to see all the related molecules/targets and research reagents of them.

Cardiovascular Biology

Angiogenesis

Adhesion Molecules in Angiogenesis

Cadherins

E-Cadherin CDH10 Cadherin-11 CDH12 H Cadherin M-Cadherin/CDH15 Cadherin 17/CDH17 N Cadherin CDH20 CDH3/P cadherin R-Cadherin/CDH4 VE-Cadherin K Cadherin/CDH6 CDH7 Cadherin 8 CDH9 CDHR5

Immunoglobulin Superfamily CAMs

CD166/ALCAM BCAM BVES CADM1 CADM2 CADM3 CADM4 CD160 CD47 CDO CEACAM1 CEACAM16 CEACAM18 CEACAM19 CEACAM20 CEACAM21 CEACAM3 CEACAM4 CEACAM5 CEACAM6 CEACAM7 CD66b ASAM Contactin-1 TAG1/Contactin 2 Contactin 3 CNTN4 CNTN5 DDX11 DSCAM ESAM JAM-A/Junctional Adhesion Molecule A HEPACAM ICAM-1 ICAM-2 CD50 ICAM4 ICAM5 IGDCC3 IGSF11 IGSF21 IGSF3 IGSF5 ISRL/-2 ISLR2 ICAP-1 JAM-2/JAM-B JAM-C JAML KIRREL KIRREL2 KIRREL3 L1CAM LAMP3/CD208 LRFN1 LRFN2 LRFN3 LRFN4 LRFN5 LSAMP MADCAM1 CD146/MCAM MDGA1 MDGA2 MFGE8 MXRA8 NCAM NCAM2 Nectin-2 NEGR1 Neurofascin Ninjurin-1 Ninjurin2 Nephrin Podocin/NPHS2 NPTN OPCML PEAR1 CD31 SIRP alpha TROP2 Thrombospondin-1/TSP1 TMEM204 TMIGD2 UBE2S VCAM1

Integrins

ITGA1/Integrin alpha 1 ITGA10/Integrin alpha 10 ITGA11/Integrin alpha 11 Integrin alpha 2 ITGA2B/CD41 Integrin alpha 3 Integrin alpha 4/CD49d/ITGA4 Integrin alpha 5/CD49e/ITGA5 ITGA6 Integrin alpha 7/ITGA7 Integrin alpha 8/ITGA8 Integrin alpha 9/ITGA9 CD11d/ITGAD CD103 LFA-1 CD11b/ITGAM/Integrin alpha M Integrin alpha V/ITGAV CD11c/ITGAX Integrin beta 1 CD18 Integrin beta 3 Integrin beta 4 Integrin beta 5/ITGB5 Integrin beta 6/ITGB6 Integrin beta 7/ITGB7 Integrin beta 8/ITGB8 ITGBL1

Selectins

E-Selectin SELL/CD62L P-Selectin

Angiogenesis Inhibitor

ADAMTS1 ADAMTS8 Angiopoietin-2 Calreticulin Chromogranin A/CHGA Collagen I/COL1A1 MMRN2 NOV/CCN3 CXCL4/PF4 TFPI2 Thrombospondin-1/TSP1 THBS2 TIMP-1 TIMP2 TIMP-3/TIMP3 TIMP-4/TIMP4

Angiogenic Activator

Angiogenin G-CSF IL-8/CXCL8 EGF FGF2 HGF PDGFA PDGF-B PDGF-C PDGF-D PLGF/PGF TGF-alpha TGF beta 1 TNF-alpha VEGFA

Angiogenic Factors

Angiopoietins, Angiopoietin-like Proteins, and Receptors

Angiopoietin-1 Angiopoietin-2 Angiopoietin-4 ANGPTL1 ANGPTL2 ANGPTL3/Angiopoietin-like 3 ANGPTL4 ANGPTL5 ANGPTL6/Angiopoietin-like 6 Angiopoietin-like 7 TIE2

FGF Family

alpha-2-macroglobulin A2ML1 FGF1 FGF10 FGF11 FGF12 FGF13 FGF14 FGF15 FGF16 FGF17 FGF18 FGF19 FGF2 FGF20 FGF21 FGF22 FGF23 FGF4 FGF5 FGF6 KGF/FGF-7 FGF9 FGFBP1 KSP37/FGFBP2 FGFBP3 FGFR1 FGFR1OP FGFR2 FGFR3 FGFR4 FGFRL1 FRS2 GLG1 Klotho beta PPP2CB PROKR2 Pentraxin 3 SHISA4 SPRY1 SPRY2 SPRY3

VEGF Family

FLT1 VEGFR3/FLT4 VEGFR2/KDR Neuropilin-1 Neuropilin-2 PLGF/PGF VEGFA VEGF B VEGF C

Intracellular Signaling Molecules in Angiogenesis

AKT1 AKT2 AKT3 ARNT/HIF1 beta CAMKI CaMKII beta/CAMK2B CDP/CUX1 EP300/p300 HIF-2-alpha FYN GRB2 HIF1AN Hsp27/HSPB1 JAK1 KLF2 MEK1 MEK2 ERK2 MAPK10/JNK3 P38 Gamma/MAPK12 P38 Delta/MAPK13 p38 ERK1/MAPK3 JNK2 MAPKAPK2/MK2 NELL1 p100/p52 Nonstructural protein 1/NS1 PAX2 PDPK1 PI3 Kinase p110 beta/PIK3CB PIK3CD PIK3R1 PKC alpha/PRKCA PRKCB PKC delta/PRKCD PKC epsilon/PRKCE PKC iota GLRX3/PRKCT PRKCZ / PKC zeta PRKD1 PTEN PTK2/FAK1 PXN RAF1 ROCK2 S6K1/RPS6KB1 SETD2 SHB smad7 SMAD9 SOCS1 Sphingosine Kinase 1 Src STAT1 STAT3 LKB1 TAL1

Angiogenesis

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