Axon Guidance and Neuron Migration

Axon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as semaphorins, ephrins and netrin. Plexins function as receptors for the repulsive axonal guidance molecules semaphorins. Intracellular domains of plexins are responsible for initiating cellular signal transduction inducing axon repulsion.

Topographic arrangement of neuronal cell bodies and axonal tracts are crucial for proper wiring of the nervous system. This involves often-coordinated neuronal migration and axon guidance during development. Most neurons migrate from their birthplace to specific topographic coordinates as they adopt the final cell fates and extend axons. The axons follow temporospatial specific guidance cues to reach the appropriate targets. When neuronal or axonal migration or their coordination is disrupted, severe consequences including neurodevelopmental disorders and neurological diseases, can arise. Neuronal and axonal migration shares some molecular mechanisms, as genes originally identified as axon guidance molecules have been increasingly shown to direct both navigation processes. This review focuses on axon guidance pathways that are shown to also direct neuronal migration in the vertebrate spinal cord.

Sino Biological lists the classification tree of Axon Guidance and Neuron Migration, click to see all the related molecules/targets and research reagents of them.

Axon Guidance and Neuron Migration

Axon Guidance and Neuron Migration

BMP Family

BMP Family

BMP Receptor

BMP Receptor

BMPs (Bone Morphogenetic Proteins)

BMPs (Bone Morphogenetic Proteins)

Ephrins & Eph Receptors

Ephrins & Eph Receptors

Eph Receptor

Eph Receptor

Hedgehog Family

Hedgehog Family

Repulsive Guidance Molecules and Receptors

Repulsive Guidance Molecules and Receptors

Slit Ligands and ROBO Receptors

Slit Ligands and ROBO Receptors

SLITRK Family

SLITRK Family