Receptor Tyrosine Kinases (RTKs)

Receptor Tyrosine Kinases (RTKs) are widely expressed transmembrane proteins that act as receptors for growth factors, neurotrophic factors, and other extracellular signaling molecules. Upon ligand binding, they undergo tyrosine phosphorylation at specific residues in the cytoplasmic tail. This leads to the binding of protein substrates and/or the establishment docking sites for adaptor proteins involved in RTK-mediated signal transduction. RTKs have critical functions in several developmental processes including regulating cell survival, proliferation, and motility. When unregulated, they play prominent roles in cancer formation. The simplest receptor tyrosine kinases (RTKs) have three domains: a ligand binding domain outside the cell, a single membrane-spanning domain, and a tyrosine kinase domain inside the cell. The ligands are usually diffusible peptides or small proteins produced elsewhere in the organism, and are typically growth factors, cytokines and hormones. In the absence of a ligand the receptor is inactive.

Sino Biological lists the classification tree of Receptor Tyrosine Kinases (RTKs), click to see all the related molecules/targets and research reagents of them.