Cancer Stem Cells (CSCs)

Cancer stem cells are rare immortal cells within a tumour that can both self-renew by dividing and give rise to many cell types that constitute the tumour, and can therefore form tumours. Such cells have been found in various types of human tumours and might be attractive targets for cancer treatment. Cancer stem cells (CSCs) are self-renewable cell types that are identified in most types of liquid and solid cancers and contributed to tumor onset, expansion, resistance, recurrence, and metastasis after therapy. CSCs are identified from the expression of cell surface markers, which is tumor-type dependent. The transition between CSCs with cancer cells and other non-CSCs occurs in cancers, which is possibly under the control of signals from CSCs and tumor microenvironment (TME), including CSC niche. Cancer-associated fibroblasts are among the most influential cells for promoting both differentiation of CSCs and dedifferentiation of non-CSCs toward attaining a CSC-like phenotype. WNT/β-catenin, transforming growth factor-β, Hedgehog, and Notch are important signals for maintaining self-renewal in CSCs. An effective therapeutic strategy relies on targeting both CSCs and non-CSCs to remove a possible chance of tumor relapse. There are multiple ways to target CSCs, including immunotherapy, hormone therapy, (mi)siRNA delivery, and gene knockout. Such approaches can be designed for suppressing CSC stemness, tumorigenic cues from TME, CSC extrinsic and/or intrinsic signaling, hypoxia or for promoting differentiation in the cells. Because of sharing a range of characteristics to normal stem/progenitor cells, CSCs must be targeted based on their unique markers and their preferential expression of antigens.

Sino Biological lists the classification tree of Cancer Stem Cells (CSCs), click to see all the related molecules/targets and research reagents of them.

Cancer Stem Cells (CSCs)

Cancer Stem Cells (CSCs)

Cancer Stem Cell Markers

Cancer Stem Cell Markers

Bladder Cancer Stem Cell Markers

Bladder Cancer Stem Cell Markers

Colon Cancer Stem Cell Markers

Colon Cancer Stem Cell Markers

Gastric Cancer Stem Cell Markers

Gastric Cancer Stem Cell Markers

Head and Neck Cancer Stem Cell Markers

Head and Neck Cancer Stem Cell Markers

Leukemia Cancer Stem Cell Markers

Leukemia Cancer Stem Cell Markers

Liver Cancer Stem Cell Markers

Liver Cancer Stem Cell Markers

Lung Cancer Stem Cell Markers

Lung Cancer Stem Cell Markers

Melanoma Cancer Stem Cell Markers

Melanoma Cancer Stem Cell Markers

Myeloma Cancer Stem Cell Markers

Myeloma Cancer Stem Cell Markers

Osteosarcoma Cancer Stem Cell Markers

Osteosarcoma Cancer Stem Cell Markers

Ovarian Cancer Stem Cell Markers

Ovarian Cancer Stem Cell Markers

Pancreatic Cancer Stem Cell Markers

Pancreatic Cancer Stem Cell Markers

Prostate Cancer Stem Cell Markers

Prostate Cancer Stem Cell Markers