Hematopoietic Stem Cells

Hematopoietic stem cells that provide long-term reconstitution can be separated from more mature hematopoietic cells that provide radioprotection and short-term repopulation. All differentiated blood cells from the lymphoid and myeloid lineages arise from HSCs. HSCs can be found in adult bone marrow, peripheral blood, and umbilical cord blood. Classic studies in mice describe two populations of Hematopoietic Stem Cells, Long Term and Short Term. Long term HSCs are capable of self renewal, while short term HSCs do not have this capacity. Short term HSCs, also called progenitor or precursor cells, can differentiate into all types of blood cells, which can be characterized by specific markers. For example, cells that differentiate into lymphocytes and granulocytes can be identified by detecting the expression of certain SLAM family receptors and Integrin alpha M/CD11b, respectively.

Sino Biological lists the classification tree of Hematopoietic Stem Cells, click to see all the related molecules/targets and research reagents of them.

Hematopoietic Stem Cells

Hematopoietic Stem Cells

Hematopoietic Stem Cell Growth Factors

Hematopoietic Stem Cell Growth Factors

BMPs (Bone Morphogenetic Proteins)

BMPs (Bone Morphogenetic Proteins)

Common beta Chain Receptor Family Ligands

Common beta Chain Receptor Family Ligands

Common gamma Chain Receptor Family Ligands

Common gamma Chain Receptor Family Ligands

Growth Differentiation Factor (GDF)

Growth Differentiation Factor (GDF)

Hedgehogs

Hedgehogs

IGF Ligands

IGF Ligands

Other Hematopoietic Stem Cell Growth Factors

Other Hematopoietic Stem Cell Growth Factors

Platelet-Derived Growth Factors (PDGFs)

Platelet-Derived Growth Factors (PDGFs)

Vascular Endothelial Growth Factors (VEGFs)

Vascular Endothelial Growth Factors (VEGFs)