Stem Cell Transcription Factors

The individual properties of hematopoietic stem cells, including self-renewal, maintenance of pluripotency, and asymmetric cell division, must depend at some level on the functions of specific transcription factors. Cellular programs regarding proliferation, potency, and cell fate determination can be mediated by signal transduction events that modulate transcription factor (TF) expression and/or activation. TFs promote the diferentiation of pluripotent embryonic stem (ES) cells derived from the inner cell mass of the blastocyst into stem or progenitor cells of all three vertebrate germ layers: ectoderm, mesoderm, and endoderm. In addition, the expression of specifc TFs is sufcient to reprogram somatic cells back to a pluripotent state. Induced pluripotent stem (iPS) cells, like ES cells, give rise to adult stem cells such as neural and epithelial stem cells. Adult stem cells function to replenish cells of the tissue in which they are found.

Sino Biological lists the classification tree of Stem Cell Transcription Factors, click to see all the related molecules/targets and research reagents of them.

Stem Cell Transcription Factors

Stem Cell Transcription Factors

Hemangioblast Transcription Factors

Hemangioblast Transcription Factors

Hepatic and Pancreatic Progenitor Cell Transcription Factors

Hepatic and Pancreatic Progenitor Cell Transcription Factors