15-PGDH Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

HPGD (15-Hydroxyprostaglandin Dehydrogenase, also known as PGDH; PGDH1; PHOAR1; 15-PGDH; SDR36C1), located on 4q34.1, is a Protein Coding gene. The gene produces a 28977 Da protein composed of 266 amino acids. HPGD catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4 and inhibits in vivo proliferation of colon cancer cells. Diseases such as Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive, 1 and Digital Clubbing, Isolated Congenital are associated with HPGD. The related pathways of HPGD include Transcriptional misregulation in cancer and Arachidonic acid metabolism.

15-PGDH Protein (2)

    15-PGDH Antibody (14)

      15-PGDH ELISA 试剂盒(即用型)& ELISA 抗体对套装(非即用型)(2)

      15-PGDH cDNA Clone (32)

      NM_000860.4

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_008278.2

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_024390.2

      克隆载体 cDNA 产品

      In lentiviral vector

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      15-PGDH 分子背景

      15-hydroxyprostaglandin dehydrogenase [NAD+], also known as Prostaglandin dehydrogenase 1, HPGD, and PGDH1, is a member of the short-chain dehydrogenases/reductases (SDR) family. Prostaglandins (PGs) play a key role in the onset of labor in many species and regulate uterine contractility and cervical dilatation. Therefore, the regulation of prostaglandin output by PG synthesizing and metabolizing enzymes in the human myometrium may determine uterine activity patterns in human labor both at preterm and at term. Prostaglandin dehydrogenase (PGDH) metabolizes prostaglandins (PGs) to render them inactive. HPGD is down-regulated by cortisol, dexamethasone, and betamethasone and down-regulated in colon cancer. It is up-regulated by TGFB1. HPGD contributes to the regulation of events that are under the control of prostaglandin levels. HPGD catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4. and inhibits in vivo proliferation of colon cancer cells. Defects in HPGD are the cause of primary hypertrophic osteoarthropathy autosomal recessive (PHOAR), cranio-osteoarthropathy (COA), and isolated congenital nail clubbing.

      15-PGDH 参考文献

      • Patel, FA. et al., 2003, J. Clin. Endocrinol. Metab. 88: 2922-33.
      • McKeown KJ, et al.,2003, J. Clin. Endocrinol. Metab. 88 (4): 1737-41.
      • Yan, M. et al., 2004, Proc. Natl. Acad. Sci. USA. 101: 17468-73.
      • Tariq, M. et al., 2009, J Med Genet. 46 (1): 14-20.

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