acnB Proteins, Antibodies, ELISA Kits Research Reagents

All acnB reagents are produced in house and quality controlled, including 7 acnB Antibody, 2 acnB ELISA, 1 acnB Protein. All acnB reagents are ready to use.

acnB Protein (1)

    acnB Antibody (7)

      acnB ELISA 试剂盒(即用型)& ELISA 抗体对套装(非即用型)(2)

      acnB 分子背景

      Escherichia coli contains two major aconitases (Acns), AcnA and AcnB. They are distantly related monomeric Fe-S proteins that contain different arrangements of four structural domains. acnA is specifically subject to SoxRS-mediated activation, whereas acnB encodes the major aconitase that is synthesized earlier in the growth cycle than AcnA. It is concluded that AcnB is the major citric acid cycle enzyme. Aconitate hydratase 2 (acnB) catalyzes the isomerization of citrate to isocitrate via cis-aconitate as well as the dehydration of 2-methylisocitrate to cis-2-methylaconitate, thus it functions as the major citric-acid-cycle enzyme during exponential growth. Escherichia coli acnB serves as either an enzymic catalyst or a mRNA-binding post-transcriptional regulator, depending on the status of its iron sulfur cluster. AcnB represents a large, distinct group of Gram-negative bacterial aconitases that have an altered domain organization relative to mitochondrial aconitase and other aconitases.

      acnB 参考文献

      • Bradbury AJ. et al., 1996, 142 (Pt 2): 389-400.
      • Cunningham L. et al., 1997, Microbiology. 143 (Pt 12): 3795-805.
      • Jordan PA. et al., 1999, Biochem J. 344 Pt 3: 739-46.
      • Williams CH. et al., 2002, Nat Struct Biol. 9(6): 447-52.

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