ACSL1 Antibodies, cDNA Clones Research Reagents

All ACSL1 reagents are produced in house and quality controlled, including 1 ACSL1 Antibody, 30 ACSL1 Gene, 1 ACSL1 qPCR. All ACSL1 reagents are ready to use.

ACSL1 Antibody (1)

    ACSL1 cDNA Clone (30)


    克隆载体 cDNA 产品

    In lentiviral vector


    克隆载体 cDNA 产品

    In lentiviral vector

    ACSL1 qPCR Primer (1)


    ACSL1 分子背景

    Long-chain acyl-CoA synthetases (ACSLs), which are responsible for activation of the most abundant long-chain fatty acids, are commonly deregulated in cancer. This deregulation is also associated with poor survival in patients with cancer. Fatty acids physiologically regulate ACSL expression, but cancer cells could hijack certain involved regulatory mechanisms to deregulate ACSLs. Among the five family isoforms, ACSL1 and ACSL4 are able to promote ungoverned cell growth, facilitate tumor invasion and evade programmed cell death. Acyl-CoA synthetase long-chain family member 1 (ACSL1), which are involved in altered lipid metabolism, lipolysis, and de novo FA synthesis in highly aggressive prostate and breast cancer cells.Global cardiac transcriptional analysis revealed differential expression of genes involved in cardiac metabolism, fibrosis, and hypertrophy development in Acsl1H-/- hearts 2 weeks after Acsl1 ablation.Short-term cardiac-specific ACSL1 inactivation resulted in metabolic and transcriptional derangements distinct from those observed upon complete ACSL1 knockout, suggesting heart-specific mTOR (mechanistic target of rapamycin) signaling that occurs during the early stages of substrate switching. The hypertrophy observed with partial Acsl1 ablation occurs in the context of normal cardiac function and is reminiscent of a physiological process, making this a useful model to study the transition from physiological to pathological hypertrophy. 

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