ADAM17 Proteins, Antibodies, cDNA Clones Research Reagents

All ADAM17 reagents are produced in house and quality controlled, including 4 ADAM17 Antibody, 20 ADAM17 Gene, 1 ADAM17 IP Kit, 1 ADAM17 Lysate, 1 ADAM17 Protein, 3 ADAM17 qPCR. All ADAM17 reagents are ready to use.

ADAM17 Protein (1)

    ADAM17 Antibody (4)

      ADAM17 cDNA Clone (20)


      In expression vector

      In lentiviral vector


      克隆载体 cDNA 产品

      In lentiviral vector

      ADAM17 Lysate (1)

        ADAM17 分子背景

        ADAM17 is a member of the ADAM protein family of disintegrins and metalloproteases. ADAM17 is ubiquitously expressed in the human colon, with increased activity in the colonic mucosa of patients with ulcerative colitis, a main form of inflammatory bowel disease. The expression of ADAM17 may be inhibited by ethanol. It is involved in the processing of tumor necrosis factor alpha (TNF-α) at the surface of the cell, and from within the intracellular membranes of the trans-Golgi network. ADAM17 also plays a role in the release of a diverse variety of membrane-anchored cytokines, cell adhesion molecules, receptors, ligands, and enzymes. ADAM17 may play a prominent role in the Notch signaling pathway, during the proteolytic release of the Notch intracellular domain (from the Notch1 receptor) that occurs following ligand binding.

        ADAM17 参考文献

        • Poghosyan. et al., 2002, J Biol Chem. 277 (7): 4999-5007.
        • Li Y. et al., 2006, Blood. 108 (7): 2275-9.
        • Peiretti. et al., 2003, J Cell Sci. 116 (10): 1949-57.

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