ADCY5 Antibodies, cDNA Clones Research Reagents

ADCY5 (Adenylate Cyclase 5), a member of the adenylate cyclase (EC 4.6.1.1) family, is a protein coding gene located on human chromosome 3q21.1. ADCY5 is also known as AC5 and FDFM. The ADCY5 protein is broadly expressed in heart, brain and other tissues. ADCY5 catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. ADCY5 mediates signaling downstream of ADRB1. ADCY5 regulates the increase of free cytosolic Ca(2+) in response to increased blood glucose levels and contributes to the regulation of Ca(2+)-dependent insulin secretion. ADCY5 is associated with some diseases, including Dyskinesia, Familial, With Facial Myokymia and Chorea, Benign Hereditary.

ADCY5 Antibody (1)

    ADCY5 cDNA Clone (1)

    NM_001199642.1

    In expression vector

    ADCY5 分子背景

    Adenyl cyclase 5, encoded by ADCY5, is a striatal-specific enzyme that converts adenosine triphosphate (ATP) into cyclic adenosine monophosphate (cAMP), an intracellular second messenger crucial for several molecular pathways. ADCY5 is a member of the membrane-bound adenylyl cyclase enzymes. Adenylyl cyclases mediate G protein-coupled receptor signaling through the synthesis of the second messenger cAMP. The activity of the encoded protein is stimulated by the Gs alpha subunit of G protein-coupled receptors and is inhibited by protein kinase A, calcium and Gi alpha subunits. Adenylyl cyclase 5 (ADCY5) mutations is associated with heterogenous syndromes: familial dyskinesia and facial myokymia; paroxysmal chorea and dystonia; autosomal-dominant chorea and dystonia; and benign hereditary chorea.

    ADCY5 参考文献

    • Carecchio M, et al. (2017) Adcy5-related movement disorders: Frequency, disease course and phenotypic variability in a cohort of paediatric patients. Parkinsonism Relat Disord 41 37-43.

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