AHCYL2 Antibodies, cDNA Clones Research Reagents

AHCYL2 (Adenosylhomocysteinase Like 2) is a protein coding gene located on human chromosome 7q32.1. AHCYL2 is also known as IRBIT2 and ADOHCYASE3. The human AHCYL2 gene encodes a 66721 Da protein containing 611 amino acids. The AHCYL2 protein is broadly expressed in colon, thyroid and other tissues. AHCYL2 may regulate the electrogenic sodium/bicarbonate cotransporter SLC4A4 activity and Mg(2+)-sensitivity. On the contrary of its homolog AHCYL1, does not regulate ITPR1 sensitivity to inositol 1,4,5-trisphosphate. AHCYL2 is related to NAD binding and adenosylhomocysteinase activity. AHCYL1 is an important paralog of AHCYL2 gene. AHCYL2 is associated with Mitochondrial Trifunctional Protein Deficiency.

AHCYL2 Antibody (1)

    AHCYL2 cDNA Clone (2)


    克隆载体 cDNA 产品

    In lentiviral vector

    AHCYL2 分子背景

    AHCYL2 (also known as KIAA0828 or long-IRBIT) is highly homologous to IRBIT and interacts with and regulates NBCe1-B similar to IRBIT. The sequence of the N-terminus of AHCYL2 is highly similar to the N-terminus of IRBIT and contains protein phosphatase 1 (PP1)-binding site, PEST domain, C-C domain, and PDZ ligand. Besides, the N-terminus of AHCYL2 contains a long IRBIT-specific N-terminal (LISN) domain. However, unlike IRBIT, AHCYL2 only weakly interacts with IP3R. The protein encoded by AHCYL2 acts as a homotetramer and may be involved in the conversion of S-adenosyl-L-homocysteine to L-homocysteine and adenosine.

    AHCYL2 参考文献

    • Yamaguchi S, et al. (2014) Ahcyl2 (long-irbit) as a potential regulator of the electrogenic na(+)-hco3(-) cotransporter nbce1-b. FEBS Lett 588 (5): 672-677.
    • Park PW, et al. (2016) Ahcyl2 upregulates nbce1-b via multiple serine residues of the pest domain-mediated association. Korean J Physiol Pharmacol 20 (4): 433-440.

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