AIM2 Proteins, Antibodies, cDNA Clones Research Reagents

All AIM2 reagents are produced in house and quality controlled, including 4 AIM2 Antibody, 30 AIM2 Gene, 1 AIM2 Lysate, 1 AIM2 Protein, 1 AIM2 qPCR. All AIM2 reagents are ready to use.

AIM2 Protein (1)

    AIM2 Antibody (4)

      AIM2 cDNA Clone (30)

      NM_004833.1

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_001013779.2

      克隆载体 cDNA 产品

      In lentiviral vector

      AIM2 qPCR Primer (1)

      AIM2 Lysate (1)

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        AIM2 分子背景

        AIM2, Absent In Melanoma 2 is a member of the interferon-inducible HIN-200 protein family that contains an amino-terminal pyrin domain and a carboxy-terminal oligonucleotide/oligosaccharide-binding domain, senses cytoplasmic DNA by means of its oligonucleotide/oligosaccharide-binding domain and interacts with ASC (apoptosis-associated speck-like protein containing a CARD) through its pyrin domain to activate caspase-1. In response to foreign cytoplasmic DNA, AIM2 forms an inflammasome, resulting in caspase activation in inflammatory cells. It had been pointed to a role of AIM2 function in both inflammation and cancer. AIM-2 antigen is expressed in a wide variety of tumor types, including neuroectodermal tumors, as well as breast, ovarian and colon carcinomas. AIM-2 could be used as a tumor antigen target for monitoring vaccine trials or to develop antigen specific active immunotherapy for glioma patients.

        AIM2 参考文献

        • Patsos G, et al. (2010) Restoration of absent in melanoma 2 (AIM2) induces G2/M cell cycle arrest and promotes invasion of colorectal cancer cells. Int J Cancer. 126(8): 1838-49.
        • Fernandes-Alnemri T, et al. (2009) AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA. Nature. 458(7237): 509-13.
        • Chen IF, et al. (2006) AIM2 suppresses human breast cancer cell proliferation in vitro and mammary tumor growth in a mouse model. Mol Cancer Ther. 5(1): 1-7.
        • Liu G, et al. (2004) AIM-2: a novel tumor antigen is expressed and presented by human glioma cells. J Immunother. 27(3): 220-6.

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