ALK-1 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

All ALK-1 reagents are produced in house and quality controlled, including 9 ALK-1 Antibody, 2 ALK-1 ELISA, 65 ALK-1 Gene, 1 ALK-1 IP Kit, 7 ALK-1 Lysate, 7 ALK-1 Protein, 3 ALK-1 qPCR. All ALK-1 reagents are ready to use.

ALK-1 Protein (7)

ALK-1 Antibody (9)

    ALK-1 ELISA 试剂盒(即用型)& ELISA 抗体对套装(非即用型)(2)

    ALK-1 cDNA Clone (65)

    NM_000020.2

    克隆载体 cDNA 产品

    In lentiviral vector

    NM_009612.2

    克隆载体 cDNA 产品

    In lentiviral vector

    NM_022441.2

    克隆载体 cDNA 产品

    In lentiviral vector

    XM_001091113.2

    克隆载体 cDNA 产品

    In lentiviral vector

    XM_534796.3

    克隆载体 cDNA 产品

    In lentiviral vector

    ALK-1 Lysate (7)

      ALK-1 分子背景

      Activin A receptor, type II-like 1 (ACVRL1), also known as ALK-1 (activin receptor-like kinase 1), is an endothelial-specific type I receptor of the TGF-beta (transforming growth factor beta) receptor family of ligands. On ligand binding, a heteromeric receptor complex forms consisting of two type II and two type I transmembrane serine/threonine kinases. ACVRL1 protein is expressed in certain blood vessels of kidney, spleen, heart and intestine, serving as an important role during vascular development. Mutations in ACVRL1 gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2 and vascular disease.

      ALK-1 参考文献

      • French Rendu-Osler network,et al. (2004) Molecular screening of ALK1/ACVRL1 and ENG genes in hereditary hemorrhagic telangiectasia in France. Hum Mutat. 23(4): 289-299.
      • Simon M, et al. (2006) Association of a polymorphism of the ACVRL1 gene with sporadic arteriovenous malformations of the central nervous system. J Neurosurg. 104(6): 945-9.
      • Argyriou L, et al. (2006) Novel mutations in the ENG and ACVRL1 genes causing hereditary hemorrhagic teleangiectasia. Int J Mol Med. 17(4):655-9.

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