Aminoacylase 1 Proteins, Antibodies, cDNA Clones Research Reagents

All Aminoacylase 1 reagents are produced in house and quality controlled, including 9 Aminoacylase 1 Antibody, 30 Aminoacylase 1 Gene, 2 Aminoacylase 1 IP Kit, 2 Aminoacylase 1 Lysate, 2 Aminoacylase 1 Protein, 2 Aminoacylase 1 qPCR. All Aminoacylase 1 reagents are ready to use.

Aminoacylase 1 Protein (2)

    Aminoacylase 1 Antibody (9)

      Aminoacylase 1 cDNA Clone (30)

      NM_000666.1

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_025371.2

      克隆载体 cDNA 产品

      In lentiviral vector

      Aminoacylase 1 Lysate (2)

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        Aminoacylase 1 分子背景

        Aminoacylase 1 (ACY1), a metalloenzyme that removes amide-linked ACY1 groups from amino acids and may play a role in regulating responses to oxidative stress. Both the C-terminal fragment found in the two-hybrid screen and full-length ACY1 co-immunoprecipitate with SphK1. Though both C-terminal and full-length proteins slightly reduce SphK1 activity measured in vitro, the C-terminal fragment inhibits while full-length ACY1 potentiates the effects of SphK1 on proliferation and apoptosis. It suggested that ACY1 physically interacts with SphK1 and may influence its physiological functions. As a homodimeric zinc-binding enzyme, Aminoacylase 1 catalyzes the hydrolysis of N alpha-acylated amino acids. Deficiency of Aminoacylase 1 due to mutations in the Aminoacylase 1 (ACY1) gene follows an autosomal-recessive trait of inheritance and is characterized by accumulation of N-acetyl amino acids in the urine.

        Aminoacylase 1 参考文献

        • Sommer A, et al. (2011) The molecular basis of aminoacylase 1 deficiency. Biochim Biophys Acta. 1812(6): 685-90.
        • Maceyka M, et al. (2004) Aminoacylase 1 is a sphingosine kinase 1-interacting protein. FEBS Lett. 568(1-3): 30-4.
        • Cook RM, et al.(1993) Human aminoacylase-1. Cloning, sequence, and expression analysis of a chromosome 3p21 gene inactivated in small cell lung cancer. J Biol Chem. 268(23): 17010-7.

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