AMPK alpha 1/PRKAA1 Antibodies, cDNA Clones Research Reagents

PRKAA1 (Protein Kinase AMP-Activated Catalytic Subunit Alpha 1) is a protein coding gene located on human chromosome 5p13.1. PRKAA1 is also known as AMPK and AMPKa1. The human PRKAA1 gene encodes a 64009 Da protein containing 559 amino acids. The PRKAA1 protein is ubiquitously expressed in gall bladder, thyroid and other tissues. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins, and Signaling by GPCR. PRKAA1 is related to transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. PRKAA2 is an important paralog of PRKAA1 gene. PRKAA1 is associated with some diseases, including Fatty Liver Disease and Wolff-Parkinson-White Syndrome.

AMPK alpha 1/PRKAA1 Antibody (1)

    AMPK alpha 1/PRKAA1 cDNA Clone (15)


    克隆载体 cDNA 产品

    In lentiviral vector

    AMPK alpha 1/PRKAA1 qPCR Primer (1)

    AMPK alpha 1/PRKAA1 分子背景

    The PRKAA1 gene encodes the catalytic alpha-subunit of 5' AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor that maintains energy homeostasis within the cell and is activated when the AMP/ATP ratio increases. Moreover, AMPK has been shown to be involved in inhibiting tumour growth and metastasis, and has also been implicated in the pathology of neurodegenerative and cardiac disorders. All 5 tested tag SNPs of the PRKAA1 gene (rs13361707, rs154268, rs3805486, rs6882903, and rs10074991) were significantly associated with gastric cancer.An inhibitor of PRKAA1 promoted the secretion of IL6, whereas an agonist of PRKAA1 suppressed the production of IL6.

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