APE1/APEX1 Proteins, Antibodies, cDNA Clones Research Reagents

All APE1/APEX1 reagents are produced in house and quality controlled, including 3 APE1/APEX1 Antibody, 60 APE1/APEX1 Gene, 3 APE1/APEX1 IP Kit, 1 APE1/APEX1 Protein, 3 APE1/APEX1 qPCR. All APE1/APEX1 reagents are ready to use.

APE1/APEX1 Protein (1)

    APE1/APEX1 Antibody (3)

      APE1/APEX1 cDNA Clone (60)

      NM_001641.3

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_009687.2

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_024148.1

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_001258109.1

      克隆载体 cDNA 产品

      In lentiviral vector

      APE1/APEX1 分子背景

      The enzyme is known to be a redox factor (Ref-1) stimulating DNA binding activity of AP-1 binding proteins such as Fos and Jun as well as a multifunctional DNA repair enzyme having 5' AP endonuclease, DNA 3' repair diesterase, 3'-5' exonuclease and DNA 3'-phosphatase activities.Although Apex mRNA was expressed ubiquitously, the levels varied significantly, suggesting organ- or tissue-specific expression of the Apex gene. The highest level was observed in the testis, relatively high levels in the thymus, spleen, kidney and brain, and the lowest level in the liver in rats. However, the present results suggested that APEX/Ref-1 gene product can interact with AP-1 binding proteins in brain, especially in the hippocampal formation, to regulate some brain functions by redox-activation.

      APE1/APEX1 参考文献

      • Ono Y, et al. (1995) Developmental expression of APEX nuclease, a multifunctional DNA repair enzyme, in mouse brains. Brain Res Dev Brain Res.86 (1-2): 1-6.
      • Tan Y, et al. (1996) cDNA cloning of rat major AP endonuclease (APEX nuclease) and analyses of its mRNA expression in rat tissues. Acta Med Okayama. 50 (1): 53-60.
      • Yao M, et al. (1999) Genomic structure of the rat major AP endonuclease gene (Apex) with an adjacent putative O-sialoglycoprotease gene (Prsmg1/Gcpl1) and a processed Apex pseudogene (Apexp1). Acta Med Okayama. 53 (6): 245-52.

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