ARF1 Proteins, Antibodies, cDNA Clones Research Reagents

All ARF1 reagents are produced in house and quality controlled, including 1 ARF1 Antibody, 71 ARF1 Gene, 1 ARF1 Protein, 3 ARF1 qPCR. All ARF1 reagents are ready to use.

ARF1 Protein (1)

    ARF1 Antibody (1)

      ARF1 cDNA Clone (71)

      BC009247

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_007476.3

      克隆载体 cDNA 产品

      In lentiviral vector

      BC061552.1

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_001193287.1

      克隆载体 cDNA 产品

      In lentiviral vector

      XM_004780601.1

      克隆载体 cDNA 产品

      In lentiviral vector

      ARF1 分子背景

      Invasion of tumor cells is a key step in metastasis that depends largely on the ability of these cells to degrade the extracellular matrix. The ARF1+ARF4 and ARF1+ARF3 pairs are both required for integrity of recycling endosomes but are involved in distinct transport pathways: the former pair regulates retrograde transport from endosomes to the TGN, whereas the latter is required for the transferrin recycling pathway from endosomes to the plasma membrane. The ADP-ribosylation factors (ARFs) 1 and 6 are small GTP-binding proteins, highly expressed and activated in several breast cancer cell lines and are associated with enhanced migration and invasiveness. ARF1 is a key role in invasion of breast cancer cells and suggest that targeting the ARF/Rho/MLC signaling axis might be a promising strategy to inhibit invasiveness and metastasis. ARF1 regulates cell migration and provide this GTPase as a target for the development of new therapeutics in triple negative breast cancer. ADP-ribosylation factor 1 (ARF1) is a crucial regulator in vesicle-mediated membrane trafficking and involved in the activation of signaling molecules. The aberrant MAPK signaling in prostate cancer is, at least in part, under the control of ARF1 and that, similar to Ras, ARF1 is a critical regulator in prostate cancer progression. ARF1 may represent a key molecular target for prostate cancer therapeutics and diagnosis.

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