ATF1 Antibodies, cDNA Clones Research Reagents

ATF1 (Activating Transcription Factor 1) is a protein coding gene located on human chromosome 12q13.12. ATF1 is also known as TREB36, EWS-ATF1 and FUS/ATF-1. The human ATF1 gene encodes a 29233 Da protein containing 271 amino acids. The ATF1 protein is ubiquitously expressed in thyroid, adrenal and other tissues. Among its related pathways are Transcriptional misregulation in cancer and Interleukin-11 Signaling Pathway. ATF1 is related to DNA-binding transcription factor activity and protein heterodimerization activity. CREB1 is an important paralog of ATF1 gene. ATF1 is associated with some diseases, including Melanoma Of Soft Tissue and Fibrous Histiocytoma.

ATF1 Antibody (2)

    ATF1 cDNA Clone (18)

    NM_005171.4

    克隆载体 cDNA 产品

    NM_007497.3

    克隆载体 cDNA 产品

    In lentiviral vector

    NM_001100895.1

    克隆载体 cDNA 产品

    In lentiviral vector

    ATF1 分子背景

    Activating transcription factor 1 (ATF1) and RAS genes were significantly up-regulated in tumours of both primary and recurrent cervical cancer mouse model, and they can also be detected in the blood exosomes of the mouse model. Our results indicated that ATF1 and RAS could be potential candidate biomarkers for cervical cancer in early diagnosis. ATF1 and RAS genes were found significantly elevated in tumours of primary and recurrent cervical cancer mouse model, and they were also detected in the blood exosomes. Therefore, ATF1 and RAS could be used as a diagnostic marker for cervical cancer in the future. The transcription factor Atf1 is known to promote cell survival during various stress conditions in Schizosaccharomyces pombe by activating the expression of appropriate genes. It can also activate transcription of other important genes responsible for cell cycle progression. An Atf1-dependent increase in the expression of cell division promoting genes will oppose activation of checkpoints necessary to ensure repairs and cell survival during stress.

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