c-Kit Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

KIT (KIT Proto-Oncogene, Receptor Tyrosine Kinase, also known as PBT; SCFR; C-Kit; CD117; MASTC), located on 4q12, is a Protein Coding gene. The gene produces a 109865 Da protein composed of 976 amino acids. The tyrosine kinase receptor KIT and its ligand, KITLG, function in hematopoiesis, melanogenesis, and gametogenesis. A soluble form of KIT (sKIT) is a glycoprotein of about 100 kD. Diseases such as Gastrointestinal Stromal Tumor and Piebald Trait are associated with KIT. The related pathways of KIT include RET signaling and Signaling by GPCR.

c-Kit Protein (9)

    c-Kit Antibody (23)

      c-Kit ELISA 试剂盒(即用型)& ELISA 抗体对套装(非即用型)(2)

      c-Kit cDNA Clone (28)

      NM_001093772.1

      克隆载体 cDNA 产品

      In expression vector

      NM_001122733.1

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_022264.1

      克隆载体 cDNA 产品

      In lentiviral vector

      c-Kit Lysate (8)

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        c-Kit 分子背景

        C-Kit is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). c-Kit contains 5 Ig-like C2-type (immunoglobulin-like) domains and 1 protein kinase domain. It belongs to the protein kinase superfamily, tyr protein kinase family, and CSF-1/PDGF receptor subfamily. C-Kit contains 5 Ig-like C2-type (immunoglobulin-like) domains and 1 protein kinase domain. C-Kit has tyrosine-protein kinase activity. Binding of the ligands leads to the autophosphorylation of KIT and its association with substrates such as phosphatidylinositol 3-kinase. Antibodies to c-Kit are widely used in immunohistochemistry to help distinguish particular types of tumor in histological tissue sections. It is used primarily in the diagnosis of GISTs. In GISTs, c-Kit staining is typically cytoplasmic, with stronger accentuation along the cell membranes. C-Kit antibodies can also be used in the diagnosis of mast cell tumors and in distinguishing seminomas from embryonal carcinomas. Mutations in the c-Kit gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous leukemia, and piebaldism. Defects in KIT are a cause of acute myelogenous leukemia (AML). AML is a malignant disease in which hematopoietic precursors are arrested in an early stage of development. Note=Somatic mutations that lead to constitutive activation of KIT are detected in AML patients.

        c-Kit 参考文献

        • Andre C, et al. (1997) Sequence analysis of two genomic regions containing the KIT and the FMS receptor tyrosine kinase genes. Genomics. 39(2):216-26.
        • Yarden Y, et al. (1987) Human proto-oncogene c-kit: a new cell surface receptor tyrosine kinase for an unidentified ligand. EMBO J. 6(11):3341-51.
        • Leong KG, et al. (2008) Generation of a prostate from a single adult stem cell. Nature. 456(7223): 804-8.
        • Edling CE, et al. (2007) c-Kit--a hematopoietic cell essential receptor tyrosine kinase. Int J Biochem Cell Biol. 39(11):1995-8.
        • McIntyre A, et al. (2005) Amplification and overexpression of the KIT gene is associated with progression in the seminoma subtype of testicular germ cell tumors of adolescents and adults. Cancer Res. 65(18):8085-9.

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