c-Maf/MAF cDNA Clones Research Reagents

MAF (MAF BZIP Transcription Factor) is a protein coding gene located on human chromosome 16q23.2. MAF is also known as CCA4, AYGRP, c-MAF and CTRCT21. The human MAF gene encodes a 38492 Da protein containing 373 amino acids. The MAF protein is ubiquitously expressed in kidney, endometrium and other tissues. Among its related pathways are Transcriptional misregulation in cancer and C-MYB transcription factor network. MAF is related to DNA-binding transcription factor activity and DNA-binding transcription activator activity, RNA polymerase II-specific. MAFA is an important paralog of MAF gene. MAF is associated with some diseases, including Ayme-Gripp Syndrome and Cataract 21, Multiple Types.

c-Maf/MAF cDNA Clone (1)


In expression vector

c-Maf/MAF 分子背景

The newly emerged Maf family proteins possess a highly conserved basic leucine zipper (bZip) domain in common and are subdivided into large and small Maf proteins. The Maf family proteins appear to regulate cell differentiation processes and also cellular functions as partner molecules of CNC family proteins. Organization of the small maf genes are highly conserved in vertebrates, suggesting an important functional contribution of the gene products. Human MAFG and MAFK are located at 17q25 and 7p22, respectively. Thus, small maf genes are not clustered in a single locus.

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