C7 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

All C7 reagents are produced in house and quality controlled, including 4 C7 Antibody, 1 C7 ELISA, 15 C7 Gene, 2 C7 Lysate, 2 C7 Protein, 1 C7 qPCR. All C7 reagents are ready to use.

C7 Protein (2)

    C7 Antibody (4)

      C7 ELISA 试剂盒(即用型)& ELISA 抗体对套装(非即用型)(1)

      C7 cDNA Clone (15)

      BC063851

      克隆载体 cDNA 产品

      In lentiviral vector

      XM_001054007.4

      克隆载体 cDNA 产品

      In lentiviral vector

      C7 qPCR Primer (1)

      C7 Lysate (2)

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        C7 分子背景

        Complement component 7 is a component of the complement system. It belongs to the complement C6/C7/C8/C9 family. It contains 1 EGF-like domain, 1 LDL-receptor class A domain, 1 MACPF domain, 2 Sushi (CCP/SCR) domains and 2 TSP type-1 domains. Complement component 7 serves as a membrane anchor. It participates in the formation of Membrane Attack Complex (MAC). People with C7 deficiency are prone to bacterial infection. It is a constituent of MAC that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. Defects in C7 are a cause of complement component 7 deficiency (C7D). A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis.

        C7 参考文献

        • Bossi F, et al. (2009) C7 is expressed on endothelial cells as a trap for the assembling terminal complement complex and may exert anti-inflammatory function. Blood. 113(15):3640-8.
        • Kuijpers TW, et al. (2010) Complement factor 7 gene mutations in relation to meningococcal infection and clinical recurrence of meningococcal disease. Mol Immunol. 47(4):671-7.
        • Thomas AD, et al. (2012) Characterization of a large genomic deletion in four Irish families with C7 deficiency. Mol Immunol. 50(1-2):57-9.

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