Cadherin 8 Proteins, Antibodies, cDNA Clones Research Reagents

All Cadherin 8 reagents are produced in house and quality controlled, including 4 Cadherin 8 Antibody, 26 Cadherin 8 Gene, 3 Cadherin 8 Lysate, 3 Cadherin 8 Protein, 2 Cadherin 8 qPCR. All Cadherin 8 reagents are ready to use.

Cadherin 8 Protein (3)

    Cadherin 8 Antibody (4)

      Cadherin 8 cDNA Clone (26)


      克隆载体 cDNA 产品

      In lentiviral vector


      克隆载体 cDNA 产品

      In lentiviral vector

      Cadherin 8 Lysate (3)


        Cadherin 8 分子背景

        Cadherins are integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Type I cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. The extracellular domain consists of five subdomains, each containing a cadherin motif, and appears to determine the specificity of the protein's homophilic cell adhesion activity. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. Cadherin 8, also known as CDH 8, is a type II classical cadherin belonging to the cadherin superfamily. As mainly expressed in brain, CDH8 is found in certain nerve cell lines, such as retinoblasts, glioma cells and neuroblasts, and is putatively involved in synaptic adhesion, axon outgrowth and guidance. Human Cadherin 8 is a 799 amino acid single-pass type Itransmembrane protein with a putative 29 aa signal sequence, and a 32 aa propeptide, a 56 aa mature extracellular domain, a 21 aa transmembrane domain and a 157 aa cytoplasmic domain. The human, mouse and rat proteins share approximately 98% homology.

        Cadherin 8 参考文献

        • Tanihara, H. et al., 1994, Cell Adhes. Comm. 2:15-26.
        • Kido, M. et al., 1998, Genomics 48:186-194.
        • Yamagata, K. et al., 1999, J. Biol. Chem. 274:19473-19479.
        • Nollet, F. et al., 2000, J. Mol. Biol. 299:551-572.
        • Blaschke, S. et al., 2002, Int. J. Cancer. 101 (4): 327-334.
        • Strausberg,R.L. et al., 2003, Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903.

        Note: Flag® is a registered trademark of Sigma Aldrich Biotechnology LP. It is used here for informational purposes only.