CANT1 Proteins, cDNA Clones Research Reagents

All CANT1 reagents are produced in house and quality controlled, including 30 CANT1 Gene, 2 CANT1 Lysate, 2 CANT1 Protein, 1 CANT1 qPCR. All CANT1 reagents are ready to use.

CANT1 Protein (2)

    CANT1 cDNA Clone (30)

    BC017655

    克隆载体 cDNA 产品

    In lentiviral vector

    NM_029502.3

    克隆载体 cDNA 产品

    In lentiviral vector

    XM_006247790.1

    克隆载体 cDNA 产品

    In lentiviral vector

    CANT1 qPCR Primer (1)

    CANT1 Lysate (2)

      CANT1 分子背景

      CANT1(calcium activated nucleotidase 1) belongs to the apyrase family. Apyrase is a calcium-activated plasma membrane-bound enzyme (magnesium can also activate it) (EC 3.6.1.5) that catalyses the hydrolysis of ATP to yield AMP and inorganic phosphate. Two isoenzymes are found in commercial preparations from S. tuberosum. One with a higher ratio of substrate selectivity for ATP: ADP and another with no selectivity. It can also act on ADP and other nucleoside triphosphates and diphosphates with the general reaction being NTP -> NDP + Pi -> NMP + 2Pi. The salivary apyrases of blood-feeding arthropods are nucleotide hydrolysing enzymes are implicated in the inhibition of host platelet aggregation through the hydrolysis of extracellular adenosine diphosphate. CANT1 functions as a calcium-dependent nucleotidase with a preference for UDP. Defects in CANT1 are the cause of desbuquois dysplasia.

      CANT1 参考文献

      • Failer BU, et al. (2002) Cloning, expression, and functional characterization of a Ca(2+)-dependent endoplasmic reticulum nucleoside diphosphatase. J Biol Chem. 277(40):36978-86.
      • Smith TM, et al. (2002) Cloning, expression, and characterization of a soluble calcium-activated nucleotidase, a human enzyme belonging to a new family of extracellular nucleotidases. Arch Biochem Biophys. 406(1):105-15.
      • Strausberg RL, et al. (2003) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci. 99(26):16899-903.

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