CARM1 Antibodies, cDNA Clones Research Reagents

CARM1 (Coactivator Associated Arginine Methyltransferase 1) is a protein coding gene located on human chromosome 19p13.2. CARM1 is also known as PRMT4. The human CARM1 gene encodes a 65854 Da protein containing 608 amino acids. The CARM1 protein is ubiquitously expressed in testis, placenta and other tissues. Among its related pathways are Organelle biogenesis and maintenance and Androgen receptor signaling pathway. CARM1 is related to protein homodimerization activity and transcription regulatory region DNA binding. PRMT3 is an important paralog of CARM1 gene. CARM1 is associated with some diseases, including Otopalatodigital Syndrome, Type I and Spinal Muscular Atrophy.

CARM1 Antibody (1)

    CARM1 cDNA Clone (3)

    NM_199141.1

    In expression vector

    In lentiviral vector

    CARM1 分子背景

    CARM1 is a protein arginine methyltransferase (PRMT) that has been firmly implicated in transcriptional regulation. Chromatin-modifying enzymes, and specifically the protein arginine methyltransferases (PRMTs), have emerged as important targets in cancer. Using conditional knockout mice, loss of CARM1 has little effect on normal hematopoiesis. Strikingly, knockout of Carm1 abrogates both the initiation and maintenance of acute myeloid leukemia (AML) driven by oncogenic transcription factors. CARM1 knockdown impairs cell-cycle progression, promotes myeloid differentiation, and ultimately induces apoptosis. utilize a selective, small-molecule inhibitor of CARM1 to validate the efficacy of CARM1 inhibition in leukemia cells in vitro and in vivo. Thus targeting CARM1 may be an effective therapeutic strategy for AML. Protein arginine methyltransferase (PRMT) 4 (also known as coactivator-associated arginine methyltransferase 1; CARM1) is involved in a variety of biological processes and is considered a candidate oncogene owing to its overexpression in several types of cancer. Selective PRMT4 inhibitors are useful tools for clarifying the molecular events regulated by PRMT4 and for validating PRMT4 as a therapeutic target. CARM1 is an arginine methyltransferase with diverse histone and non-histone substrates implicated in the regulation of cellular processes including transcriptional co-activation and RNA processing. CARM1 overexpression has been reported in multiple cancer types and has been shown to modulate oncogenic pathways in vitro studies.

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